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The ABCs of Gene CloningTranspharmers: Bioreactors for Pharmaceutical Products

The ABCs of Gene Cloning: Transpharmers: Bioreactors for Pharmaceutical Products [The application of transgenic technology to commercially important livestock is expected to generate major effects in agriculture and medicine. Three areas of development have been the focus of intensive investigation: (1) For improved desirable traits, such as increased growth rate, feed conversion, reduction of fat, improved quality of meat and milk. Growth hormone transgenes have been inserted into genomes of pig, sheep, and cow; (2) For improved resistance to diseases – A number of genes contributing to the immune system (such as heavy and light chains of an antibody that binds to a specific antigen) can be introduced to confer in vivo immunization to transgenic animals; (3) To raise transgenic animals for the production of pharmaceutical proteins – The concept of using farm animals as bioreactors has raised the prospect of a revolutionary role of livestock species. The list of proteins includes human lactoferrin, human collagen, α1-antitrypsin, blood coagulation factor, anticlotting agents, and many others.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

The ABCs of Gene CloningTranspharmers: Bioreactors for Pharmaceutical Products

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References (6)

Publisher
Springer International Publishing
Copyright
© Springer International Publishing AG, part of Springer Nature 2018
ISBN
978-3-319-77762-7
Pages
209 –211
DOI
10.1007/978-3-319-77982-9_22
Publisher site
See Chapter on Publisher Site

Abstract

[The application of transgenic technology to commercially important livestock is expected to generate major effects in agriculture and medicine. Three areas of development have been the focus of intensive investigation: (1) For improved desirable traits, such as increased growth rate, feed conversion, reduction of fat, improved quality of meat and milk. Growth hormone transgenes have been inserted into genomes of pig, sheep, and cow; (2) For improved resistance to diseases – A number of genes contributing to the immune system (such as heavy and light chains of an antibody that binds to a specific antigen) can be introduced to confer in vivo immunization to transgenic animals; (3) To raise transgenic animals for the production of pharmaceutical proteins – The concept of using farm animals as bioreactors has raised the prospect of a revolutionary role of livestock species. The list of proteins includes human lactoferrin, human collagen, α1-antitrypsin, blood coagulation factor, anticlotting agents, and many others.]

Published: May 27, 2018

Keywords: Growth Hormone Transgene; Pharmaceutical Proteins; Transgenic Animals; Revolutionary Role; Human Collagen

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