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The Art of Carbohydrate AnalysisAnalysis of Sialic AcidsSialic acids

The Art of Carbohydrate Analysis: Analysis of Sialic AcidsSialic acids [Sialic acids are a family of acidic sugars, in particular, of glycoproteins and glycolipids, where they have multiple functions in determining the overall structure and properties of these biomolecules. Moreover, they are responsible for the exposure of recognition determinants on the cell surface. Sialic acids exhibit great structural diversity (i.e., O-acetylation) and play important roles in human health and disease, in relation to the immune system, apoptosis, and in providing receptors for microbes. This chapter contains protocols and examples for the analysis of sialic acids by colorimetric, gas chromatographic, mass spectrometric, and NMR spectroscopic methods.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

The Art of Carbohydrate AnalysisAnalysis of Sialic AcidsSialic acids

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Publisher
Springer International Publishing
Copyright
© Springer Nature Switzerland AG 2021
ISBN
978-3-030-77790-6
Pages
229 –243
DOI
10.1007/978-3-030-77791-3_9
Publisher site
See Chapter on Publisher Site

Abstract

[Sialic acids are a family of acidic sugars, in particular, of glycoproteins and glycolipids, where they have multiple functions in determining the overall structure and properties of these biomolecules. Moreover, they are responsible for the exposure of recognition determinants on the cell surface. Sialic acids exhibit great structural diversity (i.e., O-acetylation) and play important roles in human health and disease, in relation to the immune system, apoptosis, and in providing receptors for microbes. This chapter contains protocols and examples for the analysis of sialic acids by colorimetric, gas chromatographic, mass spectrometric, and NMR spectroscopic methods.]

Published: Oct 24, 2021

Keywords: Gangliosides; Keto-aldononulosonic acids; KDN; KDO; Neuraminic acid; CMP-sialic acid; Avian influenza virus; Cancer; EPO; Bial’s test; GLC-EI/MS; Hydrolysis; Methanolysis; DMB labeling; RP-HPLC; NMR

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