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[This chapter briefly looks at the involvement of carbohydrates in diseases. Glycosylation of proteins is one of the most common posttranslational modifications in eukaryotic cells. Subsequently, many glycoproteins specifically decorate the cells with their glycans. Pathogenic bacteria and viruses benefit from the exuberant presence of carbohydrates on the cell surface. Their interaction with specific glycan epitopes leads to infections and inflammations. Furthermore, significant alterations of cell glycans occur during many diseases, including cancer and congenital disorders of glycosylation (CDG). Monitoring changes in glycosylation (e.g., in human serum) reveals a specific and sensitive approach to biomarker discovery and disease diagnosis.]
Published: Oct 24, 2021
Keywords: Diabetes; Bacteria; Viruses; Rheumatoid arthritis; COVID-19; HIV; AIDS; Malaria; Inflammatory bowel disease (IBD); Crohn’s disease; Pompe’s disease; Hurler’s disease; Sandhoff disease; Tay-Sachs disease; Cancer
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