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The Art of Carbohydrate AnalysisGlycobioinformatics

The Art of Carbohydrate Analysis: Glycobioinformatics [Carbohydrates, with their diverse structures, are involved in a myriad of biological processes. The enormous size of complex data obtained by glycomics studies has grown beyond manual interpretation. Advanced bioinformatic programs are required to capture the overwhelming information. This resulted in the development of several databases, collecting all discovered carbohydrate structures. In addition, programs and algorithms that assign glycan structures based on MS and NMR spectra have been developed. Nowadays, desktop tools are available to address standardized HPLC separation data to predict glycan structures. During the last three decades, different Research Institutes have initiated several glycobioinformatics systems. This chapter provides an historical overview of these initiatives, including their capacities and the URL access addresses at the moment of writing. Existing databases and tools are critically needed but their sustainability is far from being ensured.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

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References (60)

Publisher
Springer International Publishing
Copyright
© Springer Nature Switzerland AG 2021
ISBN
978-3-030-77790-6
Pages
297 –312
DOI
10.1007/978-3-030-77791-3_13
Publisher site
See Chapter on Publisher Site

Abstract

[Carbohydrates, with their diverse structures, are involved in a myriad of biological processes. The enormous size of complex data obtained by glycomics studies has grown beyond manual interpretation. Advanced bioinformatic programs are required to capture the overwhelming information. This resulted in the development of several databases, collecting all discovered carbohydrate structures. In addition, programs and algorithms that assign glycan structures based on MS and NMR spectra have been developed. Nowadays, desktop tools are available to address standardized HPLC separation data to predict glycan structures. During the last three decades, different Research Institutes have initiated several glycobioinformatics systems. This chapter provides an historical overview of these initiatives, including their capacities and the URL access addresses at the moment of writing. Existing databases and tools are critically needed but their sustainability is far from being ensured.]

Published: Oct 24, 2021

Keywords: Database; Genomics; Proteomics; CyberSpace; HPLC-MS; NMR; Glycoforum; GlycoPedia; MIRAGE; ExPASy

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