Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Sacks, W. Merryman, David Schmidt (2009)
On the biomechanics of heart valve function.Journal of biomechanics, 42 12
(1986)
Fragmentation of polypeptides by enzymic methods. In: Darbre A (Ed.), Practical Protein Chemistry: a Handbook
Michael Walsh, E. Cunnane, J. Mulvihill, A. Akyildiz, F. Gijsen, G. Holzapfel, G. Holzapfel (2014)
Uniaxial tensile testing approaches for characterisation of atherosclerotic plaques.Journal of biomechanics, 47 4
Lauren Sundby, W. Southern, Katelin Hawbaker, Jesús Trujillo, B. Perrin, J. Ervasti (2022)
Nucleotide- and Protein-Dependent Functions of Actg1Molecular Biology of the Cell, 33
D. Semenova, A. Zabirnyk, A. Lobov, J. Vaage, A. Malashicheva (2022)
Investigation of transcriptional changes underlying calcification of aortic valveCardiovascular Research
S. Prasad (2020)
Faculty Opinions recommendation of Myofibroblasts and fibrosis: mitochondrial and metabolic control of cellular differentiation.Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Jing Zhang, L. Xin, B. Shan, Weiwu Chen, Mingjie Xie, Denis Yuen, Weiming Zhang, Zefeng Zhang, G. Lajoie, B. Ma (2011)
PEAKS DB: De Novo Sequencing Assisted Database Search for Sensitive and Accurate Peptide Identification*Molecular & Cellular Proteomics : MCP, 11
G. Engelmayr, Daniel Hildebrand, Fraser Sutherland, J. Mayer, M. Sacks (2003)
A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterials.Biomaterials, 24
B. Uhal, C. Ramos, I. Joshi, A. Bifero, A. Pardo, M. Selman (1998)
Cell size, cell cycle, and α-smooth muscle actin expression by primary human lung fibroblasts.American journal of physiology. Lung cellular and molecular physiology, 275 5
A. Baji, Y. Mai, S. Wong, M. Abtahi, Pei Chen (2010)
Electrospinning of polymer nanofibers: Effects on oriented morphology, structures and tensile propertiesComposites Science and Technology, 70
Aline Nachlas, Siyi Li, Benjamin Streeter, Kenneth Morales, Fatiesa Sulejmani, David Madukauwa-David, Donald Bejleri, Wei Sun, A. Yoganathan, Michael Davis (2020)
A multilayered valve leaflet promotes cell-laden collagen type I production and aortic valve hemodynamics.Biomaterials, 240
M. Goumans, P. Dijke (2018)
TGF-β Signaling in Control of Cardiovascular Function.Cold Spring Harbor perspectives in biology, 10 2
Rachel Buchanan, M. Sacks (2013)
Interlayer micromechanics of the aortic heart valve leafletBiomechanics and Modeling in Mechanobiology, 13
M. Emmert, B. Schmitt, S. Loerakker, B. Sanders, H. Spriestersbach, E. Fioretta, L. Bruder, K. Brakmann, Sarah Motta, Valentina Lintas, Petra Dijkman, L. Frese, F. Berger, F. Baaijens, S. Hoerstrup (2018)
Computational modeling guides tissue-engineered heart valve design for long-term in vivo performance in a translational sheep modelScience Translational Medicine, 10
Nandan Nerurkar, Sounok Sen, Brendon Baker, D. Elliott, R. Mauck (2011)
Dynamic culture enhances stem cell infiltration and modulates extracellular matrix production on aligned electrospun nanofibrous scaffolds.Acta biomaterialia, 7 2
Qi Chen, A. Bruyneel, C. Carr, J. Czernuszka (2019)
Trilayer scaffold with cardiosphere-derived cells for heart valve tissue engineering.Journal of biomedical materials research. Part B, Applied biomaterials
P. Panwar, Guillaume Lamour, N. Mackenzie, Heejae Yang, F. Ko, Hongbin Li, D. Brömme (2015)
Changes in Structural-Mechanical Properties and Degradability of Collagen during Aging-associated Modifications*The Journal of Biological Chemistry, 290
S. Fraley, Pei-Hsun Wu, Lijuan He, Yunfeng Feng, Ranjini Krisnamurthy, G. Longmore, D. Wirtz (2015)
Three-dimensional matrix fiber alignment modulates cell migration and MT1-MMP utility by spatially and temporally directing protrusionsScientific Reports, 5
Mārtiņš Kalējs, P. Stradins, R. Lācis, I. Ozolanta, Janis Pavars, V. Kasyanov (2009)
St Jude Epic heart valve bioprostheses versus native human and porcine aortic valves - comparison of mechanical properties.Interactive cardiovascular and thoracic surgery, 8 5
S. Jana, A. Lerman (2019)
Behavior of valvular interstitial cells on trilayered nanofibrous substrate mimicking morphologies of heart valve leaflet.Acta biomaterialia, 85
N. Amoroso, A. D'Amore, Yi Hong, Christian Rivera, M. Sacks, W. Wagner (2012)
Microstructural manipulation of electrospun scaffolds for specific bending stiffness for heart valve tissue engineering.Acta biomaterialia, 8 12
S. Jana, A. Lerman (2020)
In vivo tissue engineering of a trilayered leaflet-shaped tissue construct.Regenerative medicine
Jia Gu, Yan Lu, Menqing Deng, M. Qiu, Yunfan Tian, Yue Ji, Pengyu Zong, Y. Shao, Rui Zheng, Bin Zhou, Wei Sun, X. Kong (2019)
Inhibition of acetylation of histones 3 and 4 attenuates aortic valve calcificationExperimental & Molecular Medicine, 51
(2009)
Microstructure of the aortic valve: implications for valvular mechanics and function
A. Porras, N. Engeland, Evelyn Marchbanks, A. McCormack, C. Bouten, M. Yacoub, N. Latif, K. Masters (2017)
Robust Generation of Quiescent Porcine Valvular Interstitial Cell CulturesJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 6
Shaohua Wu, T. Dong, Yiran Li, Mingchao Sun, Ye Qi, Jiao Liu, Mitchell Kuss, Shaojuan Chen, B. Duan (2022)
State-of-the-art review of advanced electrospun nanofiber yarn-based textiles for biomedical applicationsApplied Materials Today, 27
S. Jana, F. Franchi, A. Lerman (2021)
Fibrous heart valve leaflet substrate with native-mimicked morphology.Applied materials today, 24
S. Jana, Amrita Bhagia, A. Lerman (2019)
Optimization of polycaprolactone fibrous scaffold for heart valve tissue engineeringBiomedical Materials, 14
N. Masoumi, N. Annabi, A. Assmann, B. Larson, J. Hjortnaes, N. Alemdar, M. Kharaziha, K. Manning, J. Mayer, A. Khademhosseini (2014)
Tri-layered elastomeric scaffolds for engineering heart valve leaflets.Biomaterials, 35 27
Yuriy Snyder, S. Jana (2022)
Strategies for development of decellularized heart valve scaffolds for tissue engineering.Biomaterials
S. Pina, V. Ribeiro, Catarina Marques, F. Maia, T. Silva, Rui Reis, J. Oliveira (2019)
Scaffolding Strategies for Tissue Engineering and Regenerative Medicine ApplicationsMaterials, 12
J Wilkinson, A Darbre (1986)
Fragmentation of polypeptides by enzymic methodsPractical Protein Chemistry: a Handbook
S. Jana, F. Franchi, A. Lerman (2019)
Trilayered tissue structure with leaflet-like orientations developed through in vivo tissue engineeringBiomedical Materials, 15
S. Coffey, R. Roberts-Thomson, A. Brown, J. Carapetis, Mao Chen, M. Enriquez-Sarano, L. Zühlke, B. Prendergast (2021)
Global epidemiology of valvular heart diseaseNature Reviews Cardiology, 18
J. Kim, T. Hwang, L. Aguilar, C. Park, Cheol-Sang Kim (2016)
A Controlled Design of Aligned and Random Nanofibers for 3D Bi-functionalized Nerve Conduits Fabricated via a Novel Electrospinning Set-upScientific Reports, 6
D. Simionescu, Joseph Chen, Michael Jaeggli, Bo Wang, J. Liao (2012)
Form Follows Function: Advances in Trilayered Structure Replication for Aortic Heart Valve Tissue Engineering.Journal of healthcare engineering, 3 2
R. Blake, G. Markby, G. Culshaw, Y. Martinez-Pereira, Chi-Chien Lu, B. Corcoran (2019)
Survival of activated myofibroblasts in canine myxomatous mitral valve disease and the role of apoptosis.Research in veterinary science, 128
Shaohua Wu, B. Duan, X. Qin, J. Butcher (2017)
Living nano-micro fibrous woven fabric/hydrogel composite scaffolds for heart valve engineering.Acta biomaterialia, 51
Karthik Kodigepalli, Kaitlyn Thatcher, Toni West, D. Howsmon, F. Schoen, M. Sacks, C. Breuer, J. Lincoln (2020)
Biology and Biomechanics of the Heart Valve Extracellular MatrixJournal of Cardiovascular Development and Disease, 7
E. Fioretta, Sarah Motta, Valentina Lintas, S. Loerakker, K. Parker, F. Baaijens, V. Falk, S. Hoerstrup, M. Emmert (2020)
Next-generation tissue-engineered heart valves with repair, remodelling and regeneration capacityNature Reviews Cardiology, 18
M. Uiterwijk, A. Smits, D. Geemen, B. Klarenbosch, S. Dekker, M. Cramer, J. Rijswijk, E. Lurier, A. Luca, M. Brugmans, T. Mes, A. Bosman, E. Aikawa, P. Gründeman, C. Bouten, J. Kluin (2020)
In Situ Remodeling Overrules Bioinspired Scaffold Architecture of Supramolecular Elastomeric Tissue-Engineered Heart ValvesJACC: Basic to Translational Science, 5
S. Jana, A. Lerman, R. Simari (2015)
In Vitro Model of a Fibrosa Layer of a Heart Valve.ACS applied materials & interfaces, 7 36
Yuriy Snyder, S. Jana (2022)
Anisotropicity and flexibility in trilayered microfibrous substrates promote heart valve leaflet tissue engineeringBiomedical Materials, 17
Caroline Sanz, A. Mihaila, A. Evanghelidis, V. Diculescu, E. Butoi, M. Barsan (2022)
Quantification of cell oxygenation in 2D constructs of metallized electrospun polycaprolactone fibers encapsulating human valvular interstitial cellsJournal of Electroanalytical Chemistry
A. Quinlan, K. Billiar (2012)
Investigating the role of substrate stiffness in the persistence of valvular interstitial cell activation.Journal of biomedical materials research. Part A, 100 9
Ashley Scott, LaTonya Simon, H. Hutson, A. Porras, K. Masters (2021)
Engineering the aortic valve extracellular matrix through stages of development, aging, and disease.Journal of molecular and cellular cardiology
A. Hasan, S. Soliman, Fatima Hajj, Y. Tseng, H. Yalcin, Hany Marei (2018)
Fabrication and In Vitro Characterization of a Tissue Engineered PCL-PLLA Heart ValveScientific Reports, 8
S. Jana, David Morse, A. Lerman (2021)
Leaflet Tissue Generation from Microfibrous Heart Valve Leaflet Scaffolds with Native Characteristics.ACS applied bio materials, 4 11
M. Schroeder, Andrea Rodriguez, Kelly Speckl, Cierra Walker, Firaol Midekssa, Joseph Grim, R. Weiss, K. Anseth (2020)
Collagen Networks within 3D PEG Hydrogels Support Valvular Interstitial Cell Matrix MineralizationChemRN: Biomaterials (Topic)
Andrew Gibb, Michael Lazaropoulos, J. Elrod (2020)
Myofibroblasts and FibrosisCirculation Research, 127
Riley Hannan, S. Peirce, T. Barker (2017)
Fibroblasts: Diverse Cells Critical to Biomaterials Integration.ACS biomaterials science & engineering, 4 4
K. Ragaert, F. Somer, P. Somers, I. Baere, L. Cardon, J. Degrieck (2012)
Flexural mechanical properties of porcine aortic heart valve leaflets.Journal of the mechanical behavior of biomedical materials, 13
A. Mol, M. Lieshout, Christa Veen, S. Neuenschwander, S. Hoerstrup, F. Baaijens, C. Bouten (2005)
Fibrin as a cell carrier in cardiovascular tissue engineering applications.Biomaterials, 26 16
Yuting Li, Hao Meng, Yuan Liu, Bruce Lee (2015)
Fibrin Gel as an Injectable Biodegradable Scaffold and Cell Carrier for Tissue EngineeringThe Scientific World Journal, 2015
D. Gloeckner, K. Billiar, M. Sacks (1999)
Effects of mechanical fatigue on the bending properties of the porcine bioprosthetic heart valve.ASAIO journal, 45 1
Céline Augière, S. Megy, Rajae Malti, A. Boland, L. Zein, B. Verrier, A. Mégarbané, J. Deleuze, P. Bouvagnet (2015)
A Novel Alpha Cardiac Actin (ACTC1) Mutation Mapping to a Domain in Close Contact with Myosin Heavy Chain Leads to a Variety of Congenital Heart Defects, Arrhythmia and Possibly Midline DefectsPLoS ONE, 10
H. Tseng, Maude Cuchiara, Christopher Durst, M. Cuchiara, Chris Lin, Jennifer West, K. Grande-Allen (2013)
Fabrication and Mechanical Evaluation of Anatomically-Inspired Quasilaminate Hydrogel Structures with Layer-Specific FormulationsAnnals of Biomedical Engineering, 41
A. Liu, A. Gotlieb (2008)
Transforming growth factor-beta regulates in vitro heart valve repair by activated valve interstitial cells.The American journal of pathology, 173 5
Melissa Mendez, S. Kojima, R. Goldman (2010)
Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transitionThe FASEB Journal, 24
B. Duan, Ziying Yin, Laura Kang, R. Magin, J. Butcher (2016)
Active tissue stiffness modulation controls valve interstitial cell phenotype and osteogenic potential in 3D culture.Acta biomaterialia, 36
Shaohua Wu, Vikas Kumar, Peng Xiao, Mitchell Kuss, J. Lim, C. Guda, Jonathan Butcher, B. Duan (2020)
Age related extracellular matrix and interstitial cell phenotype in pulmonary valvesScientific Reports, 10
Lina Chen, Casey Yan, Zijian Zheng (2017)
Functional polymer surfaces for controlling cell behaviorsMaterials Today, 21
Shirdel Zandi, Behzad Imani, Gholamreza Safarpor, S. Khazaei (2021)
Self-management of patients with heart valve replacement and its clinical outcomes: a systematic reviewKardiochirurgia i Torakochirurgia Polska = Polish Journal of Cardio-Thoracic Surgery, 18
K. Moore, Reece Moore, Christina Wang, R. Norris (2020)
Tugging at the Heart Strings: The Septin Cytoskeleton in Heart Development and DiseaseJournal of Cardiovascular Development and Disease, 7
R. Greco, J. Iocono, H. Ehrlich (1998)
Hyaluronic acid stimulates human fibroblast proliferation within a collagen matrixJournal of Cellular Physiology, 177
N. Muzzio, S. Moya, Gabriela Romero (2021)
Multifunctional Scaffolds and Synergistic Strategies in Tissue Engineering and Regenerative MedicinePharmaceutics, 13
C. Santa, S. Anjo, B. Manadas (2016)
Protein precipitation of diluted samples in SDS‐containing buffer with acetone leads to higher protein recovery and reproducibility in comparison with TCA/acetone approachPROTEOMICS, 16
G. Engelmayr, Daniel Hildebrand, Fraser Sutherland, J. Mayer, M. Sacks (2002)
A novel bioreactor for the dynamic flexural stimulation of tissue engineered heart valve biomaterialsProceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology, 1
Greeshma Thrivikraman, A. Jagiełło, Victor Lai, Sandra Johnson, Mark Keating, Alshakim Nelson, Billianne Schultz, Connie Wang, A. Levine, E. Botvinick, R. Tranquillo (2021)
Cell contact guidance via sensing anisotropy of network mechanical resistanceProceedings of the National Academy of Sciences, 118
Z. Syedain, Allison Bradee, S. Kren, Doris Taylor, R. Tranquillo (2013)
Decellularized tissue-engineered heart valve leaflets with recellularization potential.Tissue engineering. Part A, 19 5-6
S. Mccullen, H. Autefage, A. Callanan, E. Gentleman, M. Stevens (2012)
Anisotropic fibrous scaffolds for articular cartilage regeneration.Tissue engineering. Part A, 18 19-20
Young-Seop Kim, Myoung‐Jin Kim, T. Koo, Jun-Dae Kim, Soonil Koun, Hyung-Jin Ham, Y. Lee, Myungchull Rhee, Sang-Yeob Yeo, T. Huh (2012)
Histone deacetylase is required for the activation of Wnt/β-catenin signaling crucial for heart valve formation in zebrafish embryos.Biochemical and biophysical research communications, 423 1
Shaohua Wu, Yiran Li, Caidan Zhang, Litao Tao, Mitchell Kuss, J. Lim, Jonathan Butcher, B. Duan (2022)
Tri‐Layered and Gel‐Like Nanofibrous Scaffolds with Anisotropic Features for Engineering Heart Valve LeafletsAdvanced Healthcare Materials, 11
Michael Lichtman, M. Otero-Viñas, V. Falanga (2016)
Transforming growth factor beta (TGF‐β) isoforms in wound healing and fibrosisWound Repair and Regeneration, 24
J. Zakko, Kevin Blum, J. Drews, Yen-Lin Wu, H. Hatoum, M. Russell, S. Gooden, M. Heitkemper, Olivia Conroy, J. Kelly, Stacey Carey, Michael Sacks, Karen Texter, E. Ragsdale, J. Strainic, Martin Bocks, Yadong Wang, L. Dasi, Aimee Armstrong, C. Breuer (2020)
Development of Tissue Engineered Heart Valves for Percutaneous Transcatheter Delivery in a Fetal Ovine ModelJACC: Basic to Translational Science, 5
It has been hypothesized that leaflet substrates with a trilayer structure and anisotropic mechanical properties could be useful for the production of functional and long-lasting tissue-engineered leaflets. To investigate the influence of the anisotropic structural and mechanical characteristics of a substrate on cells, in this study, we electrospun trilayer anisotropic fibrous substrates and randomly oriented isotropic fibrous substrates (used as controls) from polycaprolactone polymers. Consequently, the random substrates had higher radial and lower circumferential tensile properties than the trilayer substrates; however, they had similar flexural properties. Porcine valvular interstitial cells cultured on both substrates produced random and trilayer cell-cultured constructs, respectively. The trilayer cell-cultured constructs had more anisotropic mechanical properties, 17% higher cellular proliferation, 14% more extracellular matrix (i.e., collagen and glycosaminoglycan) production, and superior gene and protein expression, suggesting that more cells were in a growth state in the trilayer constructs than in the random constructs. Furthermore, the random and radial layers of the trilayer constructs had more vimentin, collagen, transforming growth factor-beta 1 (TGF-ß1), transforming growth factor-beta 3 (TGF-ß3) gene expression than in the circumferential layer of the constructs. This study verifies that the differences in structural, tensile, and anisotropic properties of the trilayer and random substrates influence the characteristics of the cells and ECM in the constructs.Graphic abstract[graphic not available: see fulltext]
Bio-Design and Manufacturing – Springer Journals
Published: Jul 1, 2023
Keywords: Heart valve leaflet; Trilayer; Tissue engineering; Fiber; Electrospinning
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.