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Sehee Kim, Chanyang Kim, Seungjoon Park (2017)
Mdivi-1 Protects Adult Rat Hippocampal Neural Stem Cells against Palmitate-Induced Oxidative Stress and ApoptosisInternational Journal of Molecular Sciences, 18
I. Degirmenci, C. Ozbayer, M. Kebapçı, H. Kurt, E. Çolak, H. Gunes (2019)
Common variants of genes encoding TLR4 and TLR4 pathway members TIRAP and IRAK1 are effective on MCP1, IL6, IL1β, and TNFα levels in type 2 diabetes and insulin resistanceInflammation Research, 68
Weilong Wang, Pengwei Ma, Wei Gao, Peiheng Lu, Xuerui Ding, Jiawei Chen, Hao Yuan, Lianjun Lu (2022)
Nrf2 Knockout Affected the Ferroptosis Signaling Pathway against Cisplatin-Induced Hair Cell-Like HEI-OC1 Cell DeathOxidative Medicine and Cellular Longevity, 2022
Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, M. Hei (2021)
Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal ratsExperimental Neurology, 345
Yangyi Zhang, Shanqi Guo, Shuo Wang, Xiaojiang Li, Dingkun Hou, Hongzheng Li, Lili Wang, Yong Xu, Bao-jie Ma, Haitao Wang, Xingkang Jiang (2021)
LncRNA OIP5-AS1 inhibits ferroptosis in prostate cancer with long-term cadmium exposure through miR-128-3p/SLC7A11 signaling.Ecotoxicology and environmental safety, 220
Melania Guerrero-Hue, C. García‐Caballero, A. Palomino-Antolin, Alfonso Rubio-Navarro, Cristina Vázquez-Carballo, C. Herencia, Diego Martín-Sánchez, Víctor Farré-Alins, J. Egea, Pablo Cannata, M. Praga, A. Ortiz, J. Egido, A. Sanz, J. Moreno (2019)
Curcumin reduces renal damage associated with rhabdomyolysis by decreasing ferroptosis‐mediated cell deathThe FASEB Journal, 33
S. Dixon, K. Lemberg, M. Lamprecht, R. Skouta, E. Zaitsev, Caroline Gleason, Darpan Patel, Andras Bauer, Alexandra Cantley, W. Yang, B. Morrison, B. Stockwell (2012)
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell DeathCell, 149
F. Kalinec, P. Webster, A. Maricle, D. Guerrero, DN Chakravarti, B. Chakravarti, R. Gellibolian, G. Kalinec (2009)
Glucocorticoid‐stimulated, transcription‐independent release of annexin A1 by cochlear Hensen cellsBritish Journal of Pharmacology, 158
Bin Yan, Daoli Xie, Yuancheng Wu, Shuli Wang, Xiaolin Zhang, Tong Zhao, Luying Liu, Peng Ma, Guqiang Li, Ying Yang, Yucheng Zhao, T. Zheng, Ruishuang Geng, Bo Li, Qingyin Zheng (2022)
Ferroptosis is involved in PGPS-induced otitis media in C57BL/6 miceCell Death Discovery, 8
Xuemin Chen, Yu-hui Liu, Shuai-fei Ji, Xinying Xue, Peng Liu, Congyu Li, Min Zhang, Yao-ming Chang, Xiao-cheng Wang (2022)
Protective effect of ginsenoside Rd on military aviation noise-induced cochlear hair cell damage in guinea pigsEnvironmental Science and Pollution Research, 30
J. Chu, Chen-Xu Liu, Rui Song, Qing-lin Li (2019)
Ferrostatin-1 protects HT-22 cells from oxidative toxicityNeural Regeneration Research, 15
M. Conrad, D. Pratt (2019)
The chemical basis of ferroptosisNature Chemical Biology, 15
Zhiwei Zheng, Dongmei Tang, Liping Zhao, Wen Li, Jinghong Han, Bing Hu, Guohui Nie, Yingzi He (2020)
Liproxstatin-1 Protects Hair Cell-Like HEI-OC1 Cells and Cochlear Hair Cells against Neomycin OtotoxicityOxidative Medicine and Cellular Longevity, 2020
B. Stockwell, J. Angeli, H. Bayır, A. Bush, M. Conrad, S. Dixon, S. Fulda, S. Gascón, Stavroula Hatzios, V. Kagan, Kay Noel, Xuejun Jiang, A. Linkermann, M. Murphy, M. Overholtzer, Atsushi Oyagi, G. Pagnussat, Jason Park, Qitao Ran, C. Rosenfeld, K. Salnikow, D. Tang, D. Tang, F. Torti, S. Torti, S. Toyokuni, K. Woerpel, Donna Zhang (2017)
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and DiseaseCell, 171
(2018)
Free fatty acids mediates human umbilical vein endothelial cells inflammation through tol l-l ike receptor-4
Pranavi Koppula, Zhuang Li, B. Gan (2020)
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapyProtein & Cell, 12
Meixiu Zhang, Cuizhe Wang, Jinxiu Wu, Xiaodan Ha, Yuchun Deng, Xueting Zhang, Jingzhou Wang, Keru Chen, Jiale Feng, Jiaojiao Zhu, Jianxin Xie, Jun Zhang (2018)
The Effect and Mechanism of KLF7 in the TLR4/NF-κB/IL-6 Inflammatory Signal Pathway of AdipocytesMediators of Inflammation, 2018
Hong-fa Yan, Ting Zou, Qing-zhang Tuo, Shuo Xu, Hua Li, A. Belaidi, P. Lei (2021)
Ferroptosis: mechanisms and links with diseasesSignal Transduction and Targeted Therapy, 6
G. Kalinec, Pru Thein, Channy Park, F. Kalinec (2016)
HEI-OC1 cells as a model for investigating drug cytotoxicityHearing Research, 335
Yangchun Xie, Yangchun Xie, W. Hou, Xinxin Song, Yan Yu, Jin Huang, Xiaofang Sun, R. Kang, D. Tang, D. Tang (2016)
Ferroptosis: process and functionCell Death and Differentiation, 23
Abstract Background Free fatty acids (FFAs) could induce inflammatory responses via various pathways. Ferroptosis is characterized by the accumulation of lipid peroxidation products and fatal reactive oxygen species derived from iron accumulation, which may be an upstream event in the inflammatory injuries. Objectives To investigate the involvement of ferroptosis during the FFAs-induced pathological hair cell inflammatory injuries and its underlying mechanisms. Material and Methods We utilized House Ear Institute-Organ of Corti 1 (HEI-OC1) cell line as an in vitro model. The palmitate acid (PA) was utilized as a substitute for FFA, with cotreatment with ferroptosis inducer RSL3 and ferroptosis inhibitor Fer-1. Cell viability, lactase dehydrogenase (LDH) release, the expressions of ferroptosis-related factors such as glutathione peroxidase-4 (GPX4), solute carrier family 7 member 11 (SLC7A11), as well as toll-like receptor 4 (TLR4), ferric ion and reactive oxygen species (ROS), and partial inflammatory cytokines were measured. Results PA treatment might induce ferroptosis in HEI-OC1 cells, manifested as decreased cell viability, upregulated LDH release, iron overload, and ROS accumulation. Several inflammatory cytokines including IL-1β, IL-6, IL-1β, IL-6, TNF-α, MCP-1, IL-13, IL-12 p40, CCL5, G-CSF, and GM-CSF were upregulated compared to the Ctr group, while GPX4 and SLC7A11 were downregulated. The expression of TLR4 in the inflammatory pathway was also upregulated. Besides, these changes were further exacerbated by RSL3 cotreatment and abolished by Fer-1 cotreatment. Conclusions and Significance Ferroptosis inhibition could alleviate the PA-induced inflammatory injuries via inactivation of TLR4 signaling pathway in HEI-OC1 cell line.
Acta Oto-Laryngologica – Taylor & Francis
Published: May 2, 2023
Keywords: Ferroptosis; free fatty acids; inflammation; lipid droplets; ototoxicity
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