Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

High plasma concentration of brain natriuretic peptide in patients with ruptured anterior communicating artery aneurysm

High plasma concentration of brain natriuretic peptide in patients with ruptured anterior... AbstractThe purpose of this study is to investigate the mechanism of increased atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in patients with subarachnoid hemorrhage due to ruptured aneurysms. ANP and BNP plasma concentrations were measured by immunoradiometoric assay in 53 patients at the day of onset of ruptured aneurysm, the correlation between values of increased ANP or BNP, and sex, age, location of ruptured aneurysm, degree of SAH, and severity of WFNS were statistically studied. The concentration of BNP in ruptured anterior communicating artery aneurysm (A-com) shows a significant elevation compared with other site aneurysms (p = 0.0007). The patients classified as WFNS Grade V, show a significantly higher concentration of BNP, compared with the patients classified as Grade I–IV (p=0.01). It is concluded that the hypersecretion of BNP, but not ANP, is caused by direct mechanical damage at the anterior hypothalamus by ruptured A-com aneurysm and a higher increase of BNP is also observed in cases suffering from severe neurological deficit. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png "Neurological Research (A Journal of Progress in Neurosurgery, Neurology and Neuro Sciences)" Taylor & Francis

High plasma concentration of brain natriuretic peptide in patients with ruptured anterior communicating artery aneurysm

4 pages

Loading next page...
 
/lp/taylor-francis/high-plasma-concentration-of-brain-natriuretic-peptide-in-patients-yeh0e2GRHE

References (18)

Publisher
Taylor & Francis
Copyright
© 2004 Maney Publishing
ISSN
1743-1328
eISSN
0161-6412
DOI
10.1179/016164104225017776
pmid
15727273
Publisher site
See Article on Publisher Site

Abstract

AbstractThe purpose of this study is to investigate the mechanism of increased atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in patients with subarachnoid hemorrhage due to ruptured aneurysms. ANP and BNP plasma concentrations were measured by immunoradiometoric assay in 53 patients at the day of onset of ruptured aneurysm, the correlation between values of increased ANP or BNP, and sex, age, location of ruptured aneurysm, degree of SAH, and severity of WFNS were statistically studied. The concentration of BNP in ruptured anterior communicating artery aneurysm (A-com) shows a significant elevation compared with other site aneurysms (p = 0.0007). The patients classified as WFNS Grade V, show a significantly higher concentration of BNP, compared with the patients classified as Grade I–IV (p=0.01). It is concluded that the hypersecretion of BNP, but not ANP, is caused by direct mechanical damage at the anterior hypothalamus by ruptured A-com aneurysm and a higher increase of BNP is also observed in cases suffering from severe neurological deficit.

Journal

"Neurological Research (A Journal of Progress in Neurosurgery, Neurology and Neuro Sciences)"Taylor & Francis

Published: Dec 1, 2004

Keywords: RUPTURED ANTERIOR COMMUNICATING ARTERY ANEURYSM; SUBARACHNOID HEMORRHAGE; BRAIN NATRIURETIC PEPTIDE; HYPOTHALAMUS

There are no references for this article.