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JD Marshall, I Bazan, Y Zhang, WH Fares, PJ Lee (2018)
Mitochondrial dysfunction and pulmonary hypertension: cause, effect, or both, 314
R Savai, SS Pullamsetti, J Kolbe, E Bieniek, R Voswinckel, L Fink, A Scheed, C Ritter, BK Dahal, A Vater, S Klussmann, HA Ghofrani, N Weissmann, W Klepetko, GA Banat, W Seeger, F Grimminger, RT Schermuly (2012)
Immune and inflammatory cell involvement in the pathology of idiopathic pulmonary arterial hypertension, 186
SS Mou, SB Haudek, L Lequier, O Peña, S Leonard, H Nikaidoh, BP Giroir, D Stromberg (2002)
Myocardial inflammatory activation in children with congenital heart disease, 30
M Lévy, C Maurey, DS Celermajer, PR Vouhe, C Danel, D Bonnet, D Israel-Biet (2007)
Impaired apoptosis of pulmonary endothelial cells is associated with intimal proliferation and irreversibility of pulmonary hypertension in congenital heart disease, 49
XH Qiao, Q Wang, J Wang, XY Liu, YJ Xu, RT Huang, S Xue, YJ Li, M Zhang, XK Qu, RG Li, XB Qiu, YQ Yang (2018)
A novel NR2F2 loss-of-function mutation predisposes to congenital heart defect, 61
SA Myers, SC Wang, GE Muscat (2006)
The chicken ovalbumin upstream promoter-transcription factors modulate genes and pathways involved in skeletal muscle cell metabolism, 281
AK Nath, RM Brown, M Michaud, MR Sierra-Honigmann, M Snyder, JA Madri (2008)
Leptin affects endocardial cushion formation by modulating EMT and migration via Akt signaling cascades, 181
FA Pereira, Y Qiu, G Zhou, MJ Tsai, SY Tsai (1999)
The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development, 13
DTB Thuan, H Zayed, AH Eid, H Abou-Saleh, GK Nasrallah, AA Mangoni, G Pintus (2018)
A potential link between oxidative stress and endothelial-to-mesenchymal transition in systemic sclerosis, 9
Y Guo, T Dorn, SJ Kühl, A Linnemann, M Rothe, AS Pfister, S Vainio, KL Laugwitz, A Moretti, M Kühl (2019)
The Wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation program in Xenopus laevis, 449
S Dimmeler, I Fleming, B Fisslthaler, C Hermann, R Busse, AM Zeiher (1999)
Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation, 399
N Takamoto, I Kurihara, K Lee, FJ Demayo, MJ Tsai, SY Tsai (2005)
Haploinsufficiency of chicken ovalbumin upstream promoter transcription factor II in female reproduction, 19
JM Elinoff, AJ Mazer, R Cai, M Lu, G Graninger, B Harper, GA Ferreyra, J Sun, MA Solomon, RL Danner (2020)
Meta-analysis of blood genome-wide expression profiling studies in pulmonary arterial hypertension, 318
E Arciniegas, MG Frid, IS Douglas, KR Stenmark (2007)
Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension, 293
L Li, X Xie, J Qin, GS Jeha, PK Saha, J Yan, CM Haueter, L Chan, SY Tsai, MJ Tsai (2009)
The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism, 9
E Nakamura, Y Makita, T Okamoto, K Nagaya, T Hayashi, M Sugimoto, H Manabe, G Taketazu, H Kajino, K Fujieda (2011)
5.78 Mb terminal deletion of chromosome 15q in a girl, evaluation of NR2F2 as candidate gene for congenital heart defects, 54
CE Evans, ND Cober, Z Dai, DJ Stewart, YY Zhao (2021)
Endothelial cells in the pathogenesis of pulmonary arterial hypertension, 58
E Erdős, BL Bálint (2019)
COUP-TFII is a modulator of cell-type-specific genetic programs based on genomic localization maps, 301
D Gomez, NC Reich (2003)
Stimulation of primary human endothelial cell proliferation by IFN, 170
X Zhang, N Tang, TJ Hadden, AK Rishi (2011)
Akt, FoxO and regulation of apoptosis, 1813
S Aggarwal, C Gross, JR Fineman, SM Black (2010)
Oxidative stress and the development of endothelial dysfunction in congenital heart disease with increased pulmonary blood flow: lessons from the neonatal lamb, 20
M Talati, A Hemnes (2015)
Fatty acid metabolism in pulmonary arterial hypertension: role in right ventricular dysfunction and hypertrophy, 5
UM Ashraf, ER Sanchez, S Kumarasamy (2019)
COUP-TFII revisited: its role in metabolic gene regulation, 141
Y Seki, H Kai, R Shibata, T Nagata, H Yasukawa, A Yoshimura, T Imaizumi (2000)
Role of the JAK/STAT pathway in rat carotid artery remodeling after vascular injury, 87
L Zuo, BA Rose, WJ Roberts, F He, AK Banes-Berceli (2014)
Molecular characterization of reactive oxygen species in systemic and pulmonary hypertension, 27
RL Benza, M Gomberg-Maitland, CG Elliott, HW Farber, AJ Foreman, AE Frost, MD McGoon, DJ Pasta, M Selej, CD Burger, RP Frantz (2019)
Predicting survival in patients with pulmonary arterial hypertension: the REVEAL risk score calculator 2.0 and comparison with ESC/ERS-based risk assessment strategies, 156
J Upadia, PR Gonzales, NH Robin (2018)
Novel de novo pathogenic variant in the NR2F2 gene in a boy with congenital heart defect and dysmorphic features, 176
I Montorfano, A Becerra, R Cerro, C Echeverría, E Sáez, MG Morales, R Fernández, C Cabello-Verrugio, F Simon (2014)
Oxidative stress mediates the conversion of endothelial cells into myofibroblasts via a TGF-β1 and TGF-β2-dependent pathway, 94
Q Chen, J Lv, W Yang, B Xu, Z Wang, Z Yu, J Wu, Y Yang, Y Han (2019)
Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis, 9
S Gairhe, KS Awad, EJ Dougherty, GA Ferreyra, S Wang, ZX Yu, K Takeda, CY Demirkale, P Torabi-Parizi, ED Austin, JM Elinoff, RL Danner (2021)
Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension, 118
JG Cho, A Lee, W Chang, MS Lee, J Kim (2018)
Endothelial to mesenchymal transition represents a key link in the interaction between inflammation and endothelial dysfunction, 9
C Ripoll, I Rivals, E Ait Yahya-Graison, L Dauphinot, E Paly, C Mircher, A Ravel, Y Grattau, H Bléhaut, A Mégarbane, G Dembour, B de Fréminville, R Touraine, N Créau, MC Potier, JM Delabar (2012)
Molecular signatures of cardiac defects in Down syndrome lymphoblastoid cell lines suggest altered ciliome and Hedgehog pathways, 7
FJ Lin, LR You, CT Yu, WH Hsu, MJ Tsai, SY Tsai (2012)
Endocardial cushion morphogenesis and coronary vessel development require chicken ovalbumin upstream promoter-transcription factor II, 32
R Wang, M Wang, J Ye, G Sun, X Sun (2021)
Mechanism overview and target mining of atherosclerosis: Endothelial cell injury in atherosclerosis is regulated by glycolysis (review), 47
FA Masri, W Xu, SA Comhair, K Asosingh, M Koo, A Vasanji, J Drazba, B Anand-Apte, SC Erzurum (2007)
Hyperproliferative apoptosis-resistant endothelial cells in idiopathic pulmonary arterial hypertension, 293
N Hermann-Kleiter, G Baier (2014)
Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions, 12
JC Kovacic, S Dimmeler, RP Harvey, T Finkel, E Aikawa, G Krenning, AH Baker (2019)
Endothelial to mesenchymal transition in cardiovascular disease: JACC state-of-the-art review, 73
SP Wu, CM Cheng, RB Lanz, T Wang, JL Respress, S Ather, W Chen, SJ Tsai, XH Wehrens, MJ Tsai, SY Tsai (2013)
Atrial identity is determined by a COUP-TFII regulatory network, 25
RS Frey, M Ushio-Fukai, AB Malik (2009)
NADPH oxidase-dependent signaling in endothelial cells: role in physiology and pathophysiology, 11
I Roger, J Milara, P Montero, J Cortijo (2021)
The role of JAK/STAT molecular pathway in vascular remodeling associated with pulmonary hypertension, 22
S Choi, J Yu, A Park, MJ Dubon, J Do, Y Kim, D Nam, J Noh, KS Park (2019)
BMP-4 enhances epithelial mesenchymal transition and cancer stem cell properties of breast cancer cells via Notch signaling, 9
RK Hopper, JR Moonen, I Diebold, A Cao, CJ Rhodes, NF Tojais, JK Hennigs, M Gu, L Wang, M Rabinovitch (2016)
In pulmonary arterial hypertension, reduced BMPR2 promotes endothelial-to-mesenchymal transition via HMGA1 and its target slug, 133
S Masuda, K Matsuura, M Anazawa, T Iwamiya, T Shimizu, T Okano (2015)
Formation of vascular network structures within cardiac cell sheets from mouse embryonic stem cells, 2
X Cui, YW Lu, V Lee, D Kim, T Dorsey, Q Wang, Y Lee, P Vincent, J Schwarz, G Dai (2015)
Venous endothelial marker COUP-TFII regulates the distinct pathologic potentials of adult arteries and veins, 5
S Ramakrishnan, BB Kukreti, L Ramakrishnan, S Salahuddin, A Pendharkar, G Karthikeyan, B Bhargava, R Juneja, S Seth, SS Kothari, A Saxena, VK Bahl (2013)
Inflammatory markers are elevated in Eisenmenger syndrome, 34
A Rodríguez-García, P Samsó, P Fontova, H Simon-Molas, A Manzano, E Castaño, JL Rosa, U Martinez-Outshoorn, F Ventura, À Navarro-Sabaté, R Bartrons (2017)
TGF-β1 targets Smad, p38 MAPK, and PI3K/Akt signaling pathways to induce PFKFB3 gene expression and glycolysis in glioblastoma cells, 284
H Kimura, K Fumoto, K Shojima, S Nojima, Y Osugi, H Tomihara, H Eguchi, Y Shintani, H Endo, M Inoue, Y Doki, M Okumura, E Morii, A Kikuchi (2016)
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression, 126
D Jonigk, H Golpon, CL Bockmeyer, L Maegel, MM Hoeper, J Gottlieb, N Nickel, K Hussein, U Maus, U Lehmann, S Janciauskiene, T Welte, A Haverich, J Rische, H Kreipe, F Laenger (2011)
Plexiform lesions in pulmonary arterial hypertension composition, architecture, and microenvironment, 179
M D'Alto, VS Mahadevan (2012)
Pulmonary arterial hypertension associated with congenital heart disease, 21
KS Awad, JM Elinoff, S Wang, S Gairhe, GA Ferreyra, R Cai, J Sun, MA Solomon, RL Danner (2016)
Raf/ERK drives the proliferative and invasive phenotype of BMPR2-silenced pulmonary artery endothelial cells, 310
K Ohta-Ogo, H Hao, H Ishibashi-Ueda, S Hirota, K Nakamura, T Ohe, H Ito (2012)
CD44 expression in plexiform lesions of idiopathic pulmonary arterial hypertension, 62
X Peng, KS Lai, P She, J Kang, T Wang, G Li, Y Zhou, J Sun, D Jin, X Xu, L Liao, J Liu, E Lee, KD Poss, TP Zhong (2021)
Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration, 13
M Zhu, X Liu, Y Wang, L Chen, L Wang, X Qin, J Xu, L Li, Y Tu, T Zhou, A Sang, E Song (2018)
YAP via interacting with STAT3 regulates VEGF-induced angiogenesis in human retinal microvascular endothelial cells, 373
K Poels, JG Schnitzler, F Waissi, JHM Levels, ESG Stroes, M Daemen, E Lutgens, AM Pennekamp, DPV De Kleijn, TTP Seijkens, J Kroon (2020)
Inhibition of PFKFB3 hampers the progression of atherosclerosis and promotes plaque stability, 8
SJ Forrester, DS Kikuchi, MS Hernandes, Q Xu, KK Griendling (2018)
Reactive oxygen species in metabolic and inflammatory signaling, 122
WJ Chae, ALM Bothwell (2019)
Dickkopf1: an immunomodulatory ligand and Wnt antagonist in pathological inflammation, 108
T Ueland, A Åkerblom, T Ghukasyan, AE Michelsen, RC Becker, M Bertilsson, A Himmelmann, SK James, A Siegbahn, RF Storey, F Kontny, P Aukrust, L Wallentin (2019)
Admission levels of DKK1 (Dickkopf-1) are associated with future cardiovascular death in patients with acute coronary syndromes, 39
E Pascall, RM Tulloh (2018)
Pulmonary hypertension in congenital heart disease, 14
S Sissaoui, J Yu, A Yan, R Li, O Yukselen, A Kucukural, LJ Zhu, ND Lawson (2020)
Genomic characterization of endothelial enhancers reveals a multifunctional role for NR2F2 in regulation of arteriovenous gene expression, 126
XL Aranguren, M Beerens, G Coppiello, C Wiese, I Vandersmissen, A Lo Nigro, CM Verfaillie, M Gessler, A Luttun (2013)
COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1, 126
LM Crowther, SC Wang, NA Eriksson, SA Myers, LA Murray, GE Muscat (2011)
Chicken ovalbumin upstream promoter-transcription factor II regulates nuclear receptor, myogenic, and metabolic gene expression in skeletal muscle cells, 43
M Johansson, FA Giger, T Fielding, C Houart (2019)
Dkk1 controls cell-cell interaction through regulation of non-nuclear β-catenin pools, 51
AF Hurlstone, AP Haramis, E Wienholds, H Begthel, J Korving, F Van Eeden, E Cuppen, D Zivkovic, RH Plasterk, H Clevers (2003)
The Wnt/β-catenin pathway regulates cardiac valve formation, 425
S Al Turki, AK Manickaraj, CL Mercer, SS Gerety, MP Hitz, S Lindsay (2016)
Rare variants in NR2F2 cause congenital heart defects in humans, 98
PM George, E Oliver, P Dorfmuller, OD Dubois, DM Reed, NS Kirkby, NA Mohamed, F Perros, F Antigny, E Fadel, BE Schreiber, AM Holmes, M Southwood, G Hagan, SJ Wort, N Bartlett, NW Morrell, JG Coghlan, M Humbert, L Zhao, JA Mitchell (2014)
Evidence for the involvement of type I interferon in pulmonary arterial hypertension, 114
P Bi, S Kuang (2015)
Notch signaling as a novel regulator of metabolism, 26
JW Moss, DP Ramji (2015)
Interferon-γ: promising therapeutic target in atherosclerosis, 5
SM Evrard, L Lecce, KC Michelis, A Nomura-Kitabayashi, G Pandey, KR Purushothaman, V d'Escamard, JR Li, L Hadri, K Fujitani, PR Moreno, L Benard, P Rimmele, A Cohain, B Mecham, GJ Randolph, EG Nabel, R Hajjar, V Fuster, M Boehm, JC Kovacic (2016)
Endothelial to mesenchymal transition is common in atherosclerotic lesions and is associated with plaque instability, 7
RL Benza, MK Kanwar, A Raina, JV Scott, CL Zhao, M Selej, CG Elliott, HW Farber (2021)
Development and validation of an abridged version of the REVEAL 2.0 risk score calculator, REVEAL Lite 2, for use in patients with pulmonary arterial hypertension, 159
T Yamazaki, Y Yoshimatsu, Y Morishita, K Miyazono, T Watabe (2009)
COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction, 14
R Rafikov, X Sun, O Rafikova, M Louise Meadows, AA Desai, Z Khalpey, JX Yuan, JR Fineman, SM Black (2015)
Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells, 6
C Brunssen, S Korten, M Brux, S Seifert, J Roesler, SR Bornstein, H Morawietz, W Goettsch (2010)
COUP-TFII is regulated by high glucose in endothelial cells, 42
R Savai, HM Al-Tamari, D Sedding, B Kojonazarov, C Muecke, R Teske, MR Capecchi, N Weissmann, F Grimminger, W Seeger, RT Schermuly, SS Pullamsetti (2014)
Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension, 20
A Mamazhakypov, G Viswanathan, A Lawrie, RT Schermuly, S Rajagopal (2021)
The role of chemokines and chemokine receptors in pulmonary arterial hypertension, 178
A Moh, W Zhang, S Yu, J Wang, X Xu, J Li, XY Fu (2008)
STAT3 sensitizes insulin signaling by negatively regulating glycogen synthase kinase-3β, 57
J Planchais, M Boutant, V Fauveau, LD Qing, L Sabra-Makke, P Bossard, M Vasseur-Cognet, JP Pégorier (2015)
The role of chicken ovalbumin upstream promoter transcription factor II in the regulation of hepatic fatty acid oxidation and gluconeogenesis in newborn mice, 308
MR Swift, VN Pham, D Castranova, K Bell, RJ Poole, BM Weinstein (2014)
SoxF factors and Notch regulate nr2f2 gene expression during venous differentiation in zebrafish, 390
T Suzuki, T Moriya, AD Darnel, J Takeyama, H Sasano (2000)
Immunohistochemical distribution of chicken ovalbumin upstream promoter transcription factor II in human tissues, 164
Y Cao, X Zhang, L Wang, Q Yang, Q Ma, J Xu, J Wang, L Kovacs, RJ Ayon, Z Liu, M Zhang, Y Zhou, X Zeng, Y Xu, Y Wang, DJ Fulton, NL Weintraub, R Lucas, Z Dong, JX Yuan, JC Sullivan, L Meadows, SA Barman, C Wu, J Quan, M Hong, Y Su, Y Huo (2019)
PFKFB3-mediated endothelial glycolysis promotes pulmonary hypertension, 116
ME Ritchie, B Phipson, D Wu, Y Hu, CW Law, W Shi, GK Smyth (2015)
limma powers differential expression analyses for RNA-sequencing and microarray studies, 43
C Gentile, RC Muise-Helmericks, CJ Drake (2013)
VEGF-mediated phosphorylation of eNOS regulates angioblast and embryonic endothelial cell proliferation, 373
H Nguyen, CV Ramana, J Bayes, GR Stark (2001)
Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression, 276
NR2F2 is expressed in endothelial cells (ECs) and Nr2f2 knockout produces lethal cardiovascular defects. In humans, reduced NR2F2 expression is associated with cardiovascular diseases including congenital heart disease and atherosclerosis. Here, NR2F2 silencing in human primary ECs led to inflammation, endothelial-to-mesenchymal transition (EndMT), proliferation, hypermigration, apoptosis-resistance, and increased production of reactive oxygen species. These changes were associated with STAT and AKT activation along with increased production of DKK1. Co-silencing DKK1 and NR2F2 prevented NR2F2-loss induced STAT and AKT activation and reversed EndMT. Serum DKK1 concentrations were elevated in patients with pulmonary arterial hypertension (PAH) and DKK1 was secreted by ECs in response to in vitro loss of either BMPR2 or CAV1, which are genetic defects associated with the development of PAH. In human primary ECs, NR2F2 suppressed DKK1, while its loss conversely induced DKK1 and disrupted endothelial homeostasis, promoting phenotypic abnormalities associated with pathologic vascular remodeling. Activating NR2F2 or blocking DKK1 may be useful therapeutic targets for treating chronic vascular diseases associated with EC dysfunction.
AJP Lung Cellular and Molecular Physiology – The American Physiological Society
Published: Jun 1, 2023
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