Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

212 Co‐delivery of Vitamin D3 and Antigens by Nanoparticles Enhances Immune Tolerance through Induction of Tolerogenic Dendritic Cells in vivo

212 Co‐delivery of Vitamin D3 and Antigens by Nanoparticles Enhances Immune Tolerance through... Tolerogenic dendritic cells (tDCs) induces regulatory T cell (Treg) differentiation and promotes immune tolerance. However, the effective generation of tDCs in vivo to treat autoimmune diseases remains a significant challenge. In this study, the potential of 1α, 25‐Dihydroxyvitamin D3 (VD3) is explored, which has been shown to promote tDCs differentiation in vitro, to induce tDCs in a mouse model of experimental autoimmune encephalomyelitis (EAE). To overcome the poor solubility of VD3 and induce autoantigen‐specific Tregs, a PLGA‐PEG‐based nano‐drug delivery system is prepared to co‐deliver VD3 and myelin‐oligodendrocyte glycoprotein (MOG) peptides. It is found that intradermal (i.d.) injection of NP/VD3/MOG significantly enhanced the level of antigen‐specific Tregs in vivo. Furthermore, NP/VD3/MOG remarkedly delayed the onset, reduced the severity, and promoted the recovery of EAE mice. This study provides an effective strategy for the treatment of autoimmune diseases. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Therapeutics Wiley

212 Co‐delivery of Vitamin D3 and Antigens by Nanoparticles Enhances Immune Tolerance through Induction of Tolerogenic Dendritic Cells in vivo

Loading next page...
 
/lp/wiley/212-co-delivery-of-vitamin-d3-and-antigens-by-nanoparticles-enhances-F2vg9ivDVf

References (4)

Publisher
Wiley
Copyright
© 2023 Wiley‐VCH GmbH
eISSN
2366-3987
DOI
10.1002/adtp.202200274
Publisher site
See Article on Publisher Site

Abstract

Tolerogenic dendritic cells (tDCs) induces regulatory T cell (Treg) differentiation and promotes immune tolerance. However, the effective generation of tDCs in vivo to treat autoimmune diseases remains a significant challenge. In this study, the potential of 1α, 25‐Dihydroxyvitamin D3 (VD3) is explored, which has been shown to promote tDCs differentiation in vitro, to induce tDCs in a mouse model of experimental autoimmune encephalomyelitis (EAE). To overcome the poor solubility of VD3 and induce autoantigen‐specific Tregs, a PLGA‐PEG‐based nano‐drug delivery system is prepared to co‐deliver VD3 and myelin‐oligodendrocyte glycoprotein (MOG) peptides. It is found that intradermal (i.d.) injection of NP/VD3/MOG significantly enhanced the level of antigen‐specific Tregs in vivo. Furthermore, NP/VD3/MOG remarkedly delayed the onset, reduced the severity, and promoted the recovery of EAE mice. This study provides an effective strategy for the treatment of autoimmune diseases.

Journal

Advanced TherapeuticsWiley

Published: Jul 1, 2023

Keywords: antigen‐specific regulatory T cells; experimental autoimmune encephalomyelitis; immune tolerance; nano‐drug delivery system; tolerogenic dendritic cells

There are no references for this article.