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Acute metaldehyde poisoning from ingestion: clinical features and implications for early treatment

Acute metaldehyde poisoning from ingestion: clinical features and implications for early treatment INTRODUCTIONMetaldehyde is a popular and potent molluscicide commonly used against slugs and snails.1,2 Toxic when ingested, it is readily absorbed in the gastrointestinal tract, causing a myriad of multisystemic complications. Despite its widespread use, reports of acute toxicity in humans are exceedingly rare when compared to other mammals. Consequently, there are significant gaps in our knowledge of the clinical features and outcomes of acute metaldehyde toxicity in humans.1 Additionally, early estimation of ingested metaldehyde dose is frequently difficult due to incomplete clinical history and circumstantial evidence during the initial phases of treatment. Point‐of‐care testing for blood metaldehyde level is often unavailable, rendering it difficult for the treating physicians to decide on the initial management and disposition of these patients. Therefore, we undertook a systematic review of relevant published reports over the past 65 years, so as to better describe the clinical characteristics of acute toxicity in humans from suicidal and accidental ingestion of metaldehyde, and to elucidate factors that influence the initial management and disposition of these patients.METHODSWe carried out a search on PubMed and Google Scholar for relevant reports over the past 65 years (1956–2021) using the keywords “metaldehyde,” “molluscicide,” “metaldehyde poisoning,” “humans,” and “metaldehyde toxicity.” Articles in languages other http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acute Medicine & Surgery Wiley

Acute metaldehyde poisoning from ingestion: clinical features and implications for early treatment

Acute metaldehyde poisoning from ingestion: clinical features and implications for early treatment

Acute Medicine & Surgery , Volume 9 (1) – Jan 1, 2022

Abstract

INTRODUCTIONMetaldehyde is a popular and potent molluscicide commonly used against slugs and snails.1,2 Toxic when ingested, it is readily absorbed in the gastrointestinal tract, causing a myriad of multisystemic complications. Despite its widespread use, reports of acute toxicity in humans are exceedingly rare when compared to other mammals. Consequently, there are significant gaps in our knowledge of the clinical features and outcomes of acute metaldehyde toxicity in humans.1 Additionally, early estimation of ingested metaldehyde dose is frequently difficult due to incomplete clinical history and circumstantial evidence during the initial phases of treatment. Point‐of‐care testing for blood metaldehyde level is often unavailable, rendering it difficult for the treating physicians to decide on the initial management and disposition of these patients. Therefore, we undertook a systematic review of relevant published reports over the past 65 years, so as to better describe the clinical characteristics of acute toxicity in humans from suicidal and accidental ingestion of metaldehyde, and to elucidate factors that influence the initial management and disposition of these patients.METHODSWe carried out a search on PubMed and Google Scholar for relevant reports over the past 65 years (1956–2021) using the keywords “metaldehyde,” “molluscicide,” “metaldehyde poisoning,” “humans,” and “metaldehyde toxicity.” Articles in languages other

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References (21)

Publisher
Wiley
Copyright
© 2022 Japanese Association for Acute Medicine
eISSN
2052-8817
DOI
10.1002/ams2.766
Publisher site
See Article on Publisher Site

Abstract

INTRODUCTIONMetaldehyde is a popular and potent molluscicide commonly used against slugs and snails.1,2 Toxic when ingested, it is readily absorbed in the gastrointestinal tract, causing a myriad of multisystemic complications. Despite its widespread use, reports of acute toxicity in humans are exceedingly rare when compared to other mammals. Consequently, there are significant gaps in our knowledge of the clinical features and outcomes of acute metaldehyde toxicity in humans.1 Additionally, early estimation of ingested metaldehyde dose is frequently difficult due to incomplete clinical history and circumstantial evidence during the initial phases of treatment. Point‐of‐care testing for blood metaldehyde level is often unavailable, rendering it difficult for the treating physicians to decide on the initial management and disposition of these patients. Therefore, we undertook a systematic review of relevant published reports over the past 65 years, so as to better describe the clinical characteristics of acute toxicity in humans from suicidal and accidental ingestion of metaldehyde, and to elucidate factors that influence the initial management and disposition of these patients.METHODSWe carried out a search on PubMed and Google Scholar for relevant reports over the past 65 years (1956–2021) using the keywords “metaldehyde,” “molluscicide,” “metaldehyde poisoning,” “humans,” and “metaldehyde toxicity.” Articles in languages other

Journal

Acute Medicine & SurgeryWiley

Published: Jan 1, 2022

Keywords: Metaldehyde; poisoning; suicide; toxicity; toxicology

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