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Crystal structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase, Hcd1, from Syntrophus aciditrophicus strain SB at 1.78 Å resolution

Crystal structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase, Hcd1, from Syntrophus... Syntrophus aciditrophicus strain SB is a model syntroph that degrades benzoate and alicyclic acids. The structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase from S. aciditrophicus strain SB (SaHcd1) was resolved at 1.78 Å resolution. SaHcd1 contains sequence motifs and structural features that belong to the short‐chain dehydrogenase/reductase (SDR) family of NADPH‐dependent oxidoreductases. SaHcd1 is proposed to concomitantly reduce NAD+ or NADP+ to NADH or NADPH, respectively, while converting 3‐hydroxypimelyl‐CoA to 3‐oxopimeyl‐CoA. Further enzymatic studies are needed to confirm the function of SaHcd1. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Crystallographica Section F Structural Biology Communications Wiley

Crystal structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase, Hcd1, from Syntrophus aciditrophicus strain SB at 1.78 Å resolution

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Publisher
Wiley
Copyright
Copyright © 2023 Wiley Subscription Services, Inc., A Wiley Company
eISSN
2053-230X
DOI
10.1107/s2053230x23004399
Publisher site
See Article on Publisher Site

Abstract

Syntrophus aciditrophicus strain SB is a model syntroph that degrades benzoate and alicyclic acids. The structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase from S. aciditrophicus strain SB (SaHcd1) was resolved at 1.78 Å resolution. SaHcd1 contains sequence motifs and structural features that belong to the short‐chain dehydrogenase/reductase (SDR) family of NADPH‐dependent oxidoreductases. SaHcd1 is proposed to concomitantly reduce NAD+ or NADP+ to NADH or NADPH, respectively, while converting 3‐hydroxypimelyl‐CoA to 3‐oxopimeyl‐CoA. Further enzymatic studies are needed to confirm the function of SaHcd1.

Journal

Acta Crystallographica Section F Structural Biology CommunicationsWiley

Published: Jun 1, 2023

Keywords: SDR‐family proteins; Hcd1; syntrophy; fatty‐acid metabolism; Syntrophus aciditrophicus

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