Crystal structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase, Hcd1, from Syntrophus aciditrophicus strain SB at 1.78 Å resolution
Crystal structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase, Hcd1, from Syntrophus...
Dinh, David M.; Thomas, Leonard M.; Karr, Elizabeth A.
2023-06-01 00:00:00
Syntrophus aciditrophicus strain SB is a model syntroph that degrades benzoate and alicyclic acids. The structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase from S. aciditrophicus strain SB (SaHcd1) was resolved at 1.78 Å resolution. SaHcd1 contains sequence motifs and structural features that belong to the short‐chain dehydrogenase/reductase (SDR) family of NADPH‐dependent oxidoreductases. SaHcd1 is proposed to concomitantly reduce NAD+ or NADP+ to NADH or NADPH, respectively, while converting 3‐hydroxypimelyl‐CoA to 3‐oxopimeyl‐CoA. Further enzymatic studies are needed to confirm the function of SaHcd1.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngActa Crystallographica Section F Structural Biology CommunicationsWileyhttp://www.deepdyve.com/lp/wiley/crystal-structure-of-a-putative-3-hydroxypimelyl-coa-dehydrogenase-DWSBDq8VoW
Crystal structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase, Hcd1, from Syntrophus aciditrophicus strain SB at 1.78 Å resolution
Syntrophus aciditrophicus strain SB is a model syntroph that degrades benzoate and alicyclic acids. The structure of a putative 3‐hydroxypimelyl‐CoA dehydrogenase from S. aciditrophicus strain SB (SaHcd1) was resolved at 1.78 Å resolution. SaHcd1 contains sequence motifs and structural features that belong to the short‐chain dehydrogenase/reductase (SDR) family of NADPH‐dependent oxidoreductases. SaHcd1 is proposed to concomitantly reduce NAD+ or NADP+ to NADH or NADPH, respectively, while converting 3‐hydroxypimelyl‐CoA to 3‐oxopimeyl‐CoA. Further enzymatic studies are needed to confirm the function of SaHcd1.
Journal
Acta Crystallographica Section F Structural Biology Communications
– Wiley
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