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Determinants of longevity: genetic, environmental and medical factors

Determinants of longevity: genetic, environmental and medical factors This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed countries the maximum lifespan as well as the mean lifespan have increased substantially over the past century. There is no evidence of a genetically determined lifespan of around 85 years. On the contrary, the biggest absolute improvement in survival in recent decades has occurred amongst 80+ year‐olds. Approximately one‐quarter of the variation in lifespan in developed countries can be attributed to genetic factors. The influence of both genetic and environmental factors on longevity can potentially be modified by medical treatment, behavioural changes and environmental improvements. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Internal Medicine Wiley

Determinants of longevity: genetic, environmental and medical factors

Journal of Internal Medicine , Volume 240 (6) – Dec 1, 1996

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References (79)

Publisher
Wiley
Copyright
Blackwell Science Ltd
ISSN
0954-6820
eISSN
1365-2796
DOI
10.1046/j.1365-2796.1996.d01-2853.x
Publisher site
See Article on Publisher Site

Abstract

This review focuses on the determinants of longevity in the industrialized world, with emphasis on results from recently established data bases. Strong evidence is now available that demonstrates that in developed countries the maximum lifespan as well as the mean lifespan have increased substantially over the past century. There is no evidence of a genetically determined lifespan of around 85 years. On the contrary, the biggest absolute improvement in survival in recent decades has occurred amongst 80+ year‐olds. Approximately one‐quarter of the variation in lifespan in developed countries can be attributed to genetic factors. The influence of both genetic and environmental factors on longevity can potentially be modified by medical treatment, behavioural changes and environmental improvements.

Journal

Journal of Internal MedicineWiley

Published: Dec 1, 1996

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