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IntroductionMigraine is a highly disabling disease with years lived with disability (YLDs) in 2019 ranking second out of 369 human diseases and first among women aged 15–49,1 affecting approximately 14% of the general population.2 Genetic, environmental, dietary, and endocrine factors are considered to be risk factors for migraine.3 In clinical practice, avoidance of these risk factors, dietary and lifestyle interventions, and early identification of clinically based indicators associated with migraine can prevent the onset and progression of migraine. However, there is still a lack of clinical predictors of migraine to enable timely intervention.Recently, the proposal of the glymphatic system has opened up a new insight into the brain. The brain's glymphatic system is currently considered to be a perivascular pathway in the central nervous system that promotes the exchange of cerebrospinal and intercellular fluids to ultimately carry solutes and waste products out of the brain.4 Studies have suggested that the impairment of the glymphatic system may be an underlying cause of sleep disorders, headaches, and cortical spreading depression (CSD).5–8 A diffusion tensor imaging (DTI) analysis of the perivascular space (DTI‐ALPS) in patients with cluster headache found that the DTI‐ALPS index was lower in patients than in healthy controls (HCs),
Annals of Clinical and Translational Neurology – Wiley
Published: Jul 1, 2023
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