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Facile Construction of Functionalized 4H‐Chromene Scaffolds via Sn(OTf)2‐Catalyzed C−H Functionalization/Cyclization Reaction and Ir‐Catalyzed Direct C−H Amidation

Facile Construction of Functionalized 4H‐Chromene Scaffolds via Sn(OTf)2‐Catalyzed C−H... An efficient strategy for the construction of 4H‐chromene scaffolds from naphthols and conjugated diketones through a sequential Sn(OTf)2‐catalyzed Friedel–Crafts type C−H functionalization/cyclization process has been described. The Ir‐catalyzed C−H amination of these products could also be performed with the assistance of the carbonyl as a weak directing group, which produced a series of amino‐modified 4H‐chromene compounds in good yields. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Facile Construction of Functionalized 4H‐Chromene Scaffolds via Sn(OTf)2‐Catalyzed C−H Functionalization/Cyclization Reaction and Ir‐Catalyzed Direct C−H Amidation

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Publisher
Wiley
Copyright
© 2023 Wiley‐VCH GmbH
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.202300140
Publisher site
See Article on Publisher Site

Abstract

An efficient strategy for the construction of 4H‐chromene scaffolds from naphthols and conjugated diketones through a sequential Sn(OTf)2‐catalyzed Friedel–Crafts type C−H functionalization/cyclization process has been described. The Ir‐catalyzed C−H amination of these products could also be performed with the assistance of the carbonyl as a weak directing group, which produced a series of amino‐modified 4H‐chromene compounds in good yields.

Journal

Asian Journal of Organic ChemistryWiley

Published: Jun 1, 2023

Keywords: amination; 4H -chromenes; cyclization; C−H functionalization; Lewis acid

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