Facile Construction of Functionalized 4H‐Chromene Scaffolds via Sn(OTf)2‐Catalyzed C−H Functionalization/Cyclization Reaction and Ir‐Catalyzed Direct C−H Amidation
Facile Construction of Functionalized 4H‐Chromene Scaffolds via Sn(OTf)2‐Catalyzed C−H...
Qi, Hongbo; He, Junxia; Yuan, Xingyu; Chen, Shufeng
2023-06-01 00:00:00
An efficient strategy for the construction of 4H‐chromene scaffolds from naphthols and conjugated diketones through a sequential Sn(OTf)2‐catalyzed Friedel–Crafts type C−H functionalization/cyclization process has been described. The Ir‐catalyzed C−H amination of these products could also be performed with the assistance of the carbonyl as a weak directing group, which produced a series of amino‐modified 4H‐chromene compounds in good yields.
http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.pngAsian Journal of Organic ChemistryWileyhttp://www.deepdyve.com/lp/wiley/facile-construction-of-functionalized-4h-chromene-scaffolds-via-sn-otf-8vk3nOxzsA
Facile Construction of Functionalized 4H‐Chromene Scaffolds via Sn(OTf)2‐Catalyzed C−H Functionalization/Cyclization Reaction and Ir‐Catalyzed Direct C−H Amidation
An efficient strategy for the construction of 4H‐chromene scaffolds from naphthols and conjugated diketones through a sequential Sn(OTf)2‐catalyzed Friedel–Crafts type C−H functionalization/cyclization process has been described. The Ir‐catalyzed C−H amination of these products could also be performed with the assistance of the carbonyl as a weak directing group, which produced a series of amino‐modified 4H‐chromene compounds in good yields.
Journal
Asian Journal of Organic Chemistry
– Wiley
Published: Jun 1, 2023
Keywords: amination; 4H -chromenes; cyclization; C−H functionalization; Lewis acid
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