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Hepatocyte transplantation: Back to the future

Hepatocyte transplantation: Back to the future Vol. 15,No. 1, 1992 HEPATOCYTE TRANSPLANTATION cytes contain intracytoplasmic glycogen, glucose-6phosphatase, urea-cycle enzymes (20, 24, 34) and cytochrome P-450 (34); secrete albumin (35);metabolize bilirubin (21); and excrete organic anions such as ”Tc-HIDA (36). Furthermore, hepatocytes transplanted into the spleen survive through the average life span of rats and mice. Studies of the fate of hepatocytes in various other ectopic sites have been less extensive. Hepatocytes transplanted into the dorsal fat pad or intraperitoneally transplanted after attachment to microcarrier beads rapidly organize and retain hepatocyte-specific features (26,281. Ultrastructural studies of hepatocytes in these sites demonstrate preservation of characteristic intracellular organelles (25, 28). Bile canalicular and stromal vascular relationships in the hepatocyte mass in the dorsal fat pad are similar to those in the normal liver (25).On the other hand, hepatocyte survival beneath the renal capsule is limited, although this may be improved by cotransplantation of pancreatic islets, which presumably results in local release of hepatotrophic factors (27). Hepatocytes transplanted at ectopic sites respond with DNA synthesis to physiological proliferative stimuli, as in response to circulating factors generated by partial hepatectomy of the host liver (37-39).Because hepatocytes tend to atrophy in the absence of portal blood supply (401, survival, proliferation http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Hepatology Wiley

Hepatocyte transplantation: Back to the future

Hepatology , Volume 15 (1) – Jan 1, 1992

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References (104)

Publisher
Wiley
Copyright
Copyright © 1992 American Association for the Study of Liver Diseases
ISSN
0270-9139
eISSN
1527-3350
DOI
10.1002/hep.1840150126
Publisher site
See Article on Publisher Site

Abstract

Vol. 15,No. 1, 1992 HEPATOCYTE TRANSPLANTATION cytes contain intracytoplasmic glycogen, glucose-6phosphatase, urea-cycle enzymes (20, 24, 34) and cytochrome P-450 (34); secrete albumin (35);metabolize bilirubin (21); and excrete organic anions such as ”Tc-HIDA (36). Furthermore, hepatocytes transplanted into the spleen survive through the average life span of rats and mice. Studies of the fate of hepatocytes in various other ectopic sites have been less extensive. Hepatocytes transplanted into the dorsal fat pad or intraperitoneally transplanted after attachment to microcarrier beads rapidly organize and retain hepatocyte-specific features (26,281. Ultrastructural studies of hepatocytes in these sites demonstrate preservation of characteristic intracellular organelles (25, 28). Bile canalicular and stromal vascular relationships in the hepatocyte mass in the dorsal fat pad are similar to those in the normal liver (25).On the other hand, hepatocyte survival beneath the renal capsule is limited, although this may be improved by cotransplantation of pancreatic islets, which presumably results in local release of hepatotrophic factors (27). Hepatocytes transplanted at ectopic sites respond with DNA synthesis to physiological proliferative stimuli, as in response to circulating factors generated by partial hepatectomy of the host liver (37-39).Because hepatocytes tend to atrophy in the absence of portal blood supply (401, survival, proliferation

Journal

HepatologyWiley

Published: Jan 1, 1992

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