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INTRODUCTIONThe overdose epidemic, borne partly from aggressive marketing and widespread prescribing, continues. Overdose deaths during 2021 surpassed 100,000 lives for the first time, with most cases related to opioids.1 This number was reached despite pandemic‐related easing of some barriers to accessing medications for opioid use disorder (MOUD), such as buprenorphine, naltrexone, and methadone.An OUD rarely occurs in isolation.2 Alcohol is particularly relevant as it is a legal substance used broadly worldwide with well‐established literature describing the shared neurobiological basis between alcohol use disorder (AUD) and OUD.3,4 This is supported by national samples showing that 25%–38% of patients with an OUD have a co‐occurring AUD.5,6Given alcohol's legal status, it is somewhat unique in comparison to other substances, however, comorbid alcohol use has been shown to negatively impact OUD treatment as it is associated with MOUD discontinuation,7 opioid relapse,8 and overdose deaths.9 Naltrexone, an opioid antagonist, is available for treatment of both AUD and OUD. Its risk of precipitated opioid withdrawal if started within 10–14 days of sustained opioid use adds a barrier to treatment initiation.10 While MOUDs are becoming more widely prescribed, in 2016, only 36.1% of substance use treatment facilities offered any MAT.11 Facilities that offer MAT versus those
The American Journal on Addictions – Wiley
Published: Nov 1, 2023
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