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Iron‐Catalyzed N, N‐formyl Ethylation of Amines

Iron‐Catalyzed N, N‐formyl Ethylation of Amines In organic synthesis, formamides are the most abundant class of compounds owing to their importance as the building blocks in synthetic and industrial organic chemistry. Formamides are also one of the most valuable intermediates produced in drug synthesis and act as precursors for the synthesis of therapeutically‐relevant molecules. Here, we developed a simple, practical, and catalytic methodology for the N‐formylation of a wide variety of amines by using iron as a catalyst. This protocol features an inexpensive iron catalyst, short reaction time, mild reaction conditions, good yields, easy workup, and tolerance of a wide variety of functional groups. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Asian Journal of Organic Chemistry Wiley

Iron‐Catalyzed N, N‐formyl Ethylation of Amines

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Publisher
Wiley
Copyright
© 2023 Wiley‐VCH GmbH
ISSN
2193-5807
eISSN
2193-5815
DOI
10.1002/ajoc.202300237
Publisher site
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Abstract

In organic synthesis, formamides are the most abundant class of compounds owing to their importance as the building blocks in synthetic and industrial organic chemistry. Formamides are also one of the most valuable intermediates produced in drug synthesis and act as precursors for the synthesis of therapeutically‐relevant molecules. Here, we developed a simple, practical, and catalytic methodology for the N‐formylation of a wide variety of amines by using iron as a catalyst. This protocol features an inexpensive iron catalyst, short reaction time, mild reaction conditions, good yields, easy workup, and tolerance of a wide variety of functional groups.

Journal

Asian Journal of Organic Chemistry – Wiley

Published: Jun 1, 2023

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