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W. Grechenig, H. Clement, S. Egner, N. Tesch, A. Weiglein, G. Peicha (2001)
Musculo-tendinous junction of the flexor carpi ulnaris muscle. An anatomical studySurgical and Radiologic Anatomy, 22
S. Cowin (2001)
Bone mechanics handbook
C. Scotti, B. Tonnarelli, A. Papadimitropoulos, A. Scherberich, S. Schaeren, A. Schauerte, J. Lopez-Rios, R. Zeller, A. Barbero, I. Martin (2010)
Recapitulation of endochondral bone formation using human adult mesenchymal stem cells as a paradigm for developmental engineeringProceedings of the National Academy of Sciences, 107
Melvin Moss (1997)
The functional matrix hypothesis revisited. 1. The role of mechanotransduction.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 112 1
H. Salisbury, S. Bhimji (2016)
Embryology, Bone, Ossification
Rintaro Yamamoto, Mizuki Izumida, Tohma Sakuraya, Kenji Emura, Takamitsu Arakawa (2021)
The ulnar nerve is surrounded by the tendon expansion of the flexor carpi ulnaris muscle at the wrist: an anatomical study of Guyon’s canalAnatomical Science International, 96
R. German, D. Hertweck, J. Sirianni, D. Swindler (1994)
Heterochrony and sexual dimorphism in the pigtailed macaque (Macaca nemestrina).American journal of physical anthropology, 93 3
K. Mustapha (2018)
Finite Element Computations in Mechanics with R: A Problem-Centered Programming Approach
D. Enlow (1968)
Wolff's law and the factor of architectonic circumstance.American journal of orthodontics, 54 11
Soohee Park (2013)
Comparison of Muscle Activation during Dominant Hand Wrist Flexion when WritingJournal of Physical Therapy Science, 25
E. Morgan, G. Unnikrisnan, A. Hussein (2018)
Bone Mechanical Properties in Healthy and Diseased States.Annual review of biomedical engineering, 20
J. D. Currey (2002)
Bones, structure and mechanics
B. Demes (2007)
In vivo bone strain and bone functional adaptation.American journal of physical anthropology, 133 1
K. J. Bathe (1996)
Finite element procedures in engineering analysis
Mara Marques, Pedro Assis, Patrícia Azeredo, Jaqueline Fleury, J. Costa, L. Gomes, D. Lima, Naiara Ribeiro, M. Biancardi, F. Santos (2022)
Aluminum intake in the neonatal phase disrupts endochondral ossification in rodents.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements, 72
H. Frost (1987)
Bone “mass” and the “mechanostat”: A proposalThe Anatomical Record, 219
V. Schöffl, I. Schöffl, S. Flohe, Yasser El-Sheikh, C. Lutter (2021)
Evaluation of a Diagnostic-Therapeutic Algorithm for Finger Epiphyseal Growth Plate Stress Injuries in Adolescent ClimbersThe American Journal of Sports Medicine, 50
Jonathan Bernhard, D. Presen, Ming Li, X. Monforte, J. Ferguson, Gabriele Leinfellner, P. Heimel, Susanna Betti, S. Shu, A. Teuschl-Woller, S. Tangl, H. Redl, G. Vunjak‐Novakovic (2022)
Effects of Endochondral and Intramembranous Ossification Pathways on Bone Tissue Formation and Vascularization in Human Tissue-Engineered GraftsCells, 11
Yusaku Masago, A. Hosoya, K. Kawasaki, S. Kawano, A. Nasu, J. Toguchida, K. Fujita, Hiroaki Nakamura, G. Kondoh, K. Nagata (2012)
The molecular chaperone Hsp47 is essential for cartilage and endochondral bone formationJournal of Cell Science, 125
Kelsey Kjosness, Jasmine Hines, C. Lovejoy, P. Reno (2014)
The pisiform growth plate is lost in humans and supports a role for Hox in growth plate formationJournal of Anatomy, 225
J Currey (1999)
What determines the bending strength of compact bone?The Journal of experimental biology, 202 Pt 18
Jie Gao, James Williams, Esra Roan (2017)
Multiscale modeling of growth plate cartilage mechanobiologyBiomechanics and Modeling in Mechanobiology, 16
Melvin Moss (1997)
The functional matrix hypothesis revisited. 3. The genomic thesis.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 112 3
Danielle Emmet, Jeremy Roberts, Katherine Yao (2022)
Update on Preventing Overuse Injuries in Youth AthletesCurrent Physical Medicine and Rehabilitation Reports, 10
S. Abe, Masahito Yamamoto (2021)
Factors Involved in Morphogenesis in the Muscle–Tendon–Bone ComplexInternational Journal of Molecular Sciences, 22
M. Moss (1981)
Genetics, epigenetics, and causation.American journal of orthodontics, 80 4
E. Mackie, Y. Ahmed, L. Tatarczuch, K. Chen, M. Mirams (2008)
Endochondral ossification: how cartilage is converted into bone in the developing skeleton.The international journal of biochemistry & cell biology, 40 1
Melvin Moss (1997)
The functional matrix hypothesis revisited. 2. The role of an osseous connected cellular network.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 112 2
O. Pearson, D. Lieberman (2004)
The aging of Wolff's "law": ontogeny and responses to mechanical loading in cortical bone.American journal of physical anthropology, Suppl 39
Osman Civan (2020)
Sesamoid bones of the hand: A multicenter studyJoint Diseases and Related Surgery, 31
Xinyue Chen, R. Hughes, N. Mullin, R. Hawkins, I. Holen, Nicola Brown, J. Hobbs (2020)
Mechanical Heterogeneity in the Bone Microenvironment as Characterised by Atomic Force MicroscopybioRxiv
J. Skedros, M. Doutré, D. Weaver (2016)
Proximate mechanisms involved in the formation of Secondary Osteon MorphotypesOsteologie, 25
V. Sarin, G. Erickson, N. Giori, A. Bergman, D. Carter (1999)
Coincident development of sesamoid bones and clues to their evolutionThe Anatomical Record, 257
Víctor Lucas, H. Dutel, S. Evans, F. Gröning, A. Sharp, P. Watson, M. Fagan (2018)
An assessment of the role of the falx cerebri and tentorium cerebelli in the cranium of the cat (Felis silvestris catus)Journal of The Royal Society Interface, 15
H. D. Bhramdat (2023)
Finite element modeling for R: Package “FEA” (0.0.2)
C. Nugteren, H. Corporaal (2014)
BonesACM Transactions on Architecture and Code Optimization (TACO), 11
D. R. Carter, G. S. Beaupre (2001)
Skeletal form and function, mechanobiology of skeletal development, aging, and regeneration
C. Adamczyk, S. Milz, T. Tischer, R. Putz, M. Benjamin (2008)
An immunohistochemical study of the extracellular matrix of entheses associated with the human pisiform boneJournal of Anatomy, 212
Melvin Moss (1997)
The functional matrix hypothesis revisited. 4. The epigenetic antithesis and the resolving synthesis.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 112 4
Shana McCormack, D. Cousminer, A. Chesi, Jonathan Mitchell, Sani Roy, H. Kalkwarf, J. Lappe, V. Gilsanz, S. Oberfield, J. Shepherd, K. Winer, A. Kelly, S. Grant, B. Zemel (2017)
Association Between Linear Growth and Bone Accrual in a Diverse Cohort of Children and AdolescentsJAMA Pediatrics, 171
A. Al Shabibi, S. R. Sirasanagandla, Z. Al Thuhli, H. Al Dhuhli, M. Al Mushaiqri, S. Jaju (2020)
Radiological study on sesamoid bones of the foot among Omani subjects, 35
R. Martin, David Burr, N.A Sharkey, D. Fyhrie (1998)
Skeletal Tissue Mechanics
Zhenxing Zhao, Yifei Li, Mengjiao Wang, Sen Zhao, Zhi-Qin Zhao, J. Fang (2020)
Mechanotransduction pathways in the regulation of cartilage chondrocyte homoeostasisJournal of Cellular and Molecular Medicine, 24
N. Curtis, Marc Jones, Junfen Shi, P. O’Higgins, S. Evans, M. Fagan (2011)
Functional Relationship between Skull Form and Feeding Mechanics in Sphenodon, and Implications for Diapsid Skull DevelopmentPLoS ONE, 6
Kelsey Kjosness, P. Reno (2019)
Identifying the homology of the short human pisiform and its lost ossification centerEvoDevo, 10
C. Little, N. Bawolin, Xiongbiao Chen (2011)
Mechanical properties of natural cartilage and tissue-engineered constructs.Tissue engineering. Part B, Reviews, 17 4
Jeonghyun Kim, Kosei Tomida, Takeo Matsumoto, T. Adachi (2022)
Spheroid culture for chondrocytes triggers the initial stage of endochondral ossificationBiotechnology and Bioengineering, 119
Yan Liu, Dan Luo, Tie Wang (2016)
Hierarchical Structures of Bone and Bioinspired Bone Tissue Engineering.Small, 12 34
H. Harris (1944)
The Pisiform BoneNature, 153
O. May (1996)
Le pisiforme : sésamoïde ou os carpienAnnales De Chirurgie De La Main Et Du Membre Superieur, 15
Ashley Torres, Jonathan Matheny, T. Keaveny, D. Taylor, C. Rimnac, C. Hernandez (2016)
Material heterogeneity in cancellous bone promotes deformation recovery after mechanical failureProceedings of the National Academy of Sciences, 113
J. Currey (1999)
The design of mineralised hard tissues for their mechanical functions.The Journal of experimental biology, 202 Pt 23
Á. Fernández-Iglesias, R. Fuente, H. Gil-Peña, L. Alonso-Durán, F. Santos, J. López (2021)
The Formation of the Epiphyseal Bone Plate Occurs via Combined Endochondral and Intramembranous-Like OssificationInternational Journal of Molecular Sciences, 22
M. Yavropoulou, J. Yovos (2016)
The molecular basis of bone mechanotransductionJournal of Musculoskeletal & Neuronal Interactions, 16
M. Wong, D. Carter (1988)
Mechanical stress and morphogenetic endochondral ossification of the sternum.The Journal of bone and joint surgery. American volume, 70 7
The role of mechanical stimuli in promoting endochondral ossification during somatic growth and maturation remains an active area of research. This study employs a pisiform model of endochondral ossification to investigate the potential role of mechanobiological signals in the appearance and development of ossification centers and to develop theoretical applications to the primate basicranium. We constructed finite element models based on the structure of a human pisiform within the flexor carpi ulnaris tendon. The pisiform was assigned initial material properties of hyaline cartilage, and tendon properties were based on in situ observations drawn from the literature. A macaque growth model was used to simulate increased load over time as a function of body mass. A load case of uniaxial tension from the tendon was applied over 208 iterations, to simulate weekly growth over a 4‐year span. The mechanical signal was defined as shear stress. Element stresses were evaluated in each iteration, with elements exceeding the yield threshold subsequently assigned a higher elastic modulus to mimic mechanically driven mineralization. Three unique mineralization rates were tested. Regardless of rate, all ossification simulations predict a pisiform with heterogeneous stiffness through alternating periods of material stasis and active mineralization/ossification. Assuming metabolic processes underlying endochondral ossification are similar throughout the body, our model suggests that a mechanical signal alone is an insufficient stimulus in the etiology of bone formation through endochondral ossification. Consequently, given the general validity of the simulation, endochondral ossification cannot be fully explained in terms of mechanical stimuli.
The Anatomical Record – Wiley
Published: Jun 7, 2023
Keywords: biomechanics; finite element; shear strain; skeletal growth
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