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INTRODUCTIONErectile dysfunction (ED) refers to the absence of the ability to achieve or sustain an erection and achieve satisfactory sexuality.1 More than 150 million men worldwide are reported to have ED. The number of ED patients might exceed 320 million by 2025.2 Aging, diabetes, and cardiovascular disease are common causes of ED.3 Phosphodiesterase type 5 inhibitors (PDE5Is) are used to treat ED as first‐line drugs. However, PDE5Is are ineffective in approximately 35% of ED patients.4 The effectiveness of ED treatment may be greatly improved by using different treatment protocols according to different etiologies.DNA methylation is a form of chemical modification of DNA that can affect gene expression without altering the DNA sequence through the action of DNA methyltransferases. The methyltransferase family includes DNMT1, DNMT3a, and DNMT3b.5,6 DNMT1 plays a vital role in maintaining DNA methylation, and knockout of DNMT1 causes two‐thirds of DNA methylation to be lost in embryos, which is accompanied by a large amount of cell apoptosis, indicating that DNMT1 plays a critical role in cell differentiation and development. DNMT3a and DNMT3b are new methyltransferases that transfer methyl groups to unmethylated DNA sequences. Knockdown of DNMT3a and DNMT3b revealed that normal cell differentiation requires DNMT3a and that
Andrology – Wiley
Published: Jan 1, 2024
Keywords: androgen; diabetes; eNOS; erectile function; methylation
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