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Multiple Kaposi's sarcoma nodules successfully treated by curettage and vincristine injections in the same session

Multiple Kaposi's sarcoma nodules successfully treated by curettage and vincristine injections in... Kaposi's sarcoma (KS) is a malignancy caused by the reactivation of human herpes virus 8 (HHV8) infecting lymphatic endothelial cells.1 Clinical manifestations of KS include angiomatous patches, plaques and nodules on the skin and can rarely involve visceral organs.Local therapy is the cornerstone of treating KS confined to a few locations of the skin, but literature regarding cases with multiple nodules and combined local treatments is limited.Here, we report a locally aggressive case of cutaneous KS successfully treated with the combination of local chemotherapy and curettage.An HIV‐negative 56‐year‐old man, diagnosed with African KS 4 years earlier, was referred to our KS‐dedicated tertiary centre. He showed numerous angiomatous nodules on the right limb, including two confluent and exophytic nodules of 2 cm and 1 cm on the little finger of the right hand (Figures 1a,b and 2a,b). The clinical features were compatible with KS, and this diagnosis was later confirmed by histopathology.1FIGUREClinical images showing multiple Kaposi's sarcoma nodules on the palm (a) and dorsum (b) of the right hand, including two voluminous exophytic nodules on the little finger, before (a) and after curettage (inset). Six weeks after treatment, complete remission of the nodules was noticed (c, d).2FIGURENumerous Kaposi's sarcoma nodules on the forearm (a) http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Australasian Journal of Dermatology Wiley

Multiple Kaposi's sarcoma nodules successfully treated by curettage and vincristine injections in the same session

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References (6)

Publisher
Wiley
Copyright
Copyright © 2023 The Australasian College of Dermatologists
ISSN
0004-8380
eISSN
1440-0960
DOI
10.1111/ajd.14075
Publisher site
See Article on Publisher Site

Abstract

Kaposi's sarcoma (KS) is a malignancy caused by the reactivation of human herpes virus 8 (HHV8) infecting lymphatic endothelial cells.1 Clinical manifestations of KS include angiomatous patches, plaques and nodules on the skin and can rarely involve visceral organs.Local therapy is the cornerstone of treating KS confined to a few locations of the skin, but literature regarding cases with multiple nodules and combined local treatments is limited.Here, we report a locally aggressive case of cutaneous KS successfully treated with the combination of local chemotherapy and curettage.An HIV‐negative 56‐year‐old man, diagnosed with African KS 4 years earlier, was referred to our KS‐dedicated tertiary centre. He showed numerous angiomatous nodules on the right limb, including two confluent and exophytic nodules of 2 cm and 1 cm on the little finger of the right hand (Figures 1a,b and 2a,b). The clinical features were compatible with KS, and this diagnosis was later confirmed by histopathology.1FIGUREClinical images showing multiple Kaposi's sarcoma nodules on the palm (a) and dorsum (b) of the right hand, including two voluminous exophytic nodules on the little finger, before (a) and after curettage (inset). Six weeks after treatment, complete remission of the nodules was noticed (c, d).2FIGURENumerous Kaposi's sarcoma nodules on the forearm (a)

Journal

Australasian Journal of DermatologyWiley

Published: Aug 1, 2023

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