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Plasmodium falciparum parasites induce interferon production in human peripheral blood ‘null’ cells in vitro

Plasmodium falciparum parasites induce interferon production in human peripheral blood ‘null’... Summary Human peripheral blood mononuclear cells were found to produce interferon (IFN) when stimulated by free P. falciparum parasites in vitro. On the other hand parasite‐infected, intact erythrocytes were unable to induce IFN synthesis. When the IFN was characterized according to sensitivity to anti‐IFN‐α antibodies and pH 2 treatment it was found to consist of IFN‐α. Cell fractionation procedures and analysis of each cell fraction with regard to natural killer (NK) cell activity and IFN‐producing capacity revealed that both activities were confined to the same cell fraction. The possible relevance of the IFN‐NK cell system in malaria is discussed. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Parasite Immunology Wiley

Plasmodium falciparum parasites induce interferon production in human peripheral blood ‘null’ cells in vitro

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References (32)

Publisher
Wiley
Copyright
Copyright © 1983 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0141-9838
eISSN
1365-3024
DOI
10.1111/j.1365-3024.1983.tb00734.x
Publisher site
See Article on Publisher Site

Abstract

Summary Human peripheral blood mononuclear cells were found to produce interferon (IFN) when stimulated by free P. falciparum parasites in vitro. On the other hand parasite‐infected, intact erythrocytes were unable to induce IFN synthesis. When the IFN was characterized according to sensitivity to anti‐IFN‐α antibodies and pH 2 treatment it was found to consist of IFN‐α. Cell fractionation procedures and analysis of each cell fraction with regard to natural killer (NK) cell activity and IFN‐producing capacity revealed that both activities were confined to the same cell fraction. The possible relevance of the IFN‐NK cell system in malaria is discussed.

Journal

Parasite ImmunologyWiley

Published: Mar 1, 1983

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