Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Subcorneal pustular dermatosis treated successfully with apremilast

Subcorneal pustular dermatosis treated successfully with apremilast BACKGROUNDSubcorneal pustular dermatosis (SCPD), also known as Sneddon–Wilkinson disease, is a rare dermatological disease characterised by chronic neutrophilic pustules.1 The pathophysiology is unclear as the mechanism by which neutrophils accumulate in the skin is under investigation. Although the disease is not infective, histopathology shows neutrophilic infiltrate and occasional eosinophils in the subcorneal layer.1,2The disease most commonly affects women between 50 and 70 years old.1 The pustules are distributed symmetrically across the trunk, intertriginous and flexural regions of the proximal limbs (Figure 1).1–4 The pin‐point lesions can spread to form an annular pattern (Figure 2).2–4 Often the pustules coalesce into larger vesicles, which can become secondarily infected. The disease can cause itch, but its appearance is most concerning for patients.3,4 The natural history of the disease is that each pustule will spontaneously rupture and heal with hyperpigmentation.11FIGURETruncal distribution of SWD.2FIGUREAnnular pattern of disease in SWD.Neutrophilic disorders including SCPD are often associated with autoimmune and haematological disorders. Case reports have noted associations with diseases such as Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, myeloma and chronic lymphocytic and myelocytic leukaemia.1 There are also rarer reports of drug‐induced SCPD due to sorafenib and adalimumab.1The differential diagnosis includes acute generalised exanthematous pustulosis. This causes erythema and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Australasian Journal of Dermatology Wiley

Subcorneal pustular dermatosis treated successfully with apremilast

Loading next page...
 
/lp/wiley/subcorneal-pustular-dermatosis-treated-successfully-with-apremilast-8SiIz2mguk

References (10)

Publisher
Wiley
Copyright
Copyright © 2023 The Australasian College of Dermatologists
ISSN
0004-8380
eISSN
1440-0960
DOI
10.1111/ajd.14073
Publisher site
See Article on Publisher Site

Abstract

BACKGROUNDSubcorneal pustular dermatosis (SCPD), also known as Sneddon–Wilkinson disease, is a rare dermatological disease characterised by chronic neutrophilic pustules.1 The pathophysiology is unclear as the mechanism by which neutrophils accumulate in the skin is under investigation. Although the disease is not infective, histopathology shows neutrophilic infiltrate and occasional eosinophils in the subcorneal layer.1,2The disease most commonly affects women between 50 and 70 years old.1 The pustules are distributed symmetrically across the trunk, intertriginous and flexural regions of the proximal limbs (Figure 1).1–4 The pin‐point lesions can spread to form an annular pattern (Figure 2).2–4 Often the pustules coalesce into larger vesicles, which can become secondarily infected. The disease can cause itch, but its appearance is most concerning for patients.3,4 The natural history of the disease is that each pustule will spontaneously rupture and heal with hyperpigmentation.11FIGURETruncal distribution of SWD.2FIGUREAnnular pattern of disease in SWD.Neutrophilic disorders including SCPD are often associated with autoimmune and haematological disorders. Case reports have noted associations with diseases such as Sjogren's syndrome, systemic lupus erythematosus, rheumatoid arthritis, myeloma and chronic lymphocytic and myelocytic leukaemia.1 There are also rarer reports of drug‐induced SCPD due to sorafenib and adalimumab.1The differential diagnosis includes acute generalised exanthematous pustulosis. This causes erythema and

Journal

Australasian Journal of DermatologyWiley

Published: Aug 1, 2023

There are no references for this article.