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Technical note: Measures of differentiation for quantitative traits

Technical note: Measures of differentiation for quantitative traits Studies of anthropological genetics and bioarcheology often examine the degree of among‐group variation in quantitative traits such as craniometrics and anthropometrics. One comparative index of among‐group differentiation is the minimum value of Wright's FST as estimated from quantitative traits. This measure has been used in certain population‐genetic applications such as comparison with FST estimated from genetic data, although some inferences are limited by how well the data and study design fit the underlying population‐genetic model. In many cases, all that is needed is a simple measure of among‐group variation. One such measure is R2, the proportion of total phenotypic variation accounted for by among‐group phenotypic variation, a measure easily obtained from analysis of variance and regression methods. This paper shows that R2 and minimum FST are closely related as MinFST≈R2/2−R2. R2 is computationally easy and may be useful in cases where all we need is a simple measure of relative among‐group differentiation. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Physical Anthropology Wiley

Technical note: Measures of differentiation for quantitative traits

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References (31)

Publisher
Wiley
Copyright
© 2023 Wiley Periodicals LLC.
ISSN
0002-9483
eISSN
1096-8644
DOI
10.1002/ajpa.24760
Publisher site
See Article on Publisher Site

Abstract

Studies of anthropological genetics and bioarcheology often examine the degree of among‐group variation in quantitative traits such as craniometrics and anthropometrics. One comparative index of among‐group differentiation is the minimum value of Wright's FST as estimated from quantitative traits. This measure has been used in certain population‐genetic applications such as comparison with FST estimated from genetic data, although some inferences are limited by how well the data and study design fit the underlying population‐genetic model. In many cases, all that is needed is a simple measure of among‐group variation. One such measure is R2, the proportion of total phenotypic variation accounted for by among‐group phenotypic variation, a measure easily obtained from analysis of variance and regression methods. This paper shows that R2 and minimum FST are closely related as MinFST≈R2/2−R2. R2 is computationally easy and may be useful in cases where all we need is a simple measure of relative among‐group differentiation.

Journal

American Journal of Physical AnthropologyWiley

Published: Jul 1, 2023

Keywords: analysis of variance; F ST; R 2; quantitative traits

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