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The quantity and quality of cardiovascular fat at mid‐life and future cognitive performance among women: The SWAN cardiovascular fat ancillary study

The quantity and quality of cardiovascular fat at mid‐life and future cognitive performance among... BACKGROUNDWomen account for about two thirds of Alzheimer's disease (AD) cases among individuals > 65 years old in the United States.1 The deposition of brain amyloid beta (Aβ) can be tracked back to mid‐life,2 which overlaps with the menopause transition. As women traverse menopause, they experience an acceleration of cardiovascular disease (CVD) risk3 including a gain in fat mass,4 particularly abdominal visceral fat.5 Mid‐life cardiovascular risk has been linked to a faster cognitive decline6 and a higher risk of dementia in later life.7 In addition, abdominal visceral fat has been associated with poor cognitive performance.8 Thus, the menopause transition may be a stage of vulnerability for subsequent cognitive impairment and dementia. Characterizing risk factors that deteriorate across the menopause transition may aid in early prevention of dementia, a disease with a natural history of pathological changes spanning decades starting in mid‐life.9Cardiovascular fat is a novel CVD risk factor10–15 that was found to be higher after than before menopause.16 Cardiovascular fat consists of epicardial adipose tissue (EAT; located within the pericardial sac), paracardial adipose tissue (PAT; outside the pericardial sac), and thoracic perivascular adipose tissue (PVAT; surrounding the descending thoracic aorta). Human EAT and PAT morphologically resemble white and beige http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alzheimer s & Dementia Wiley

The quantity and quality of cardiovascular fat at mid‐life and future cognitive performance among women: The SWAN cardiovascular fat ancillary study

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References (60)

Publisher
Wiley
Copyright
© 2023 the Alzheimer's Association.
ISSN
1552-5260
eISSN
1552-5279
DOI
10.1002/alz.13133
Publisher site
See Article on Publisher Site

Abstract

BACKGROUNDWomen account for about two thirds of Alzheimer's disease (AD) cases among individuals > 65 years old in the United States.1 The deposition of brain amyloid beta (Aβ) can be tracked back to mid‐life,2 which overlaps with the menopause transition. As women traverse menopause, they experience an acceleration of cardiovascular disease (CVD) risk3 including a gain in fat mass,4 particularly abdominal visceral fat.5 Mid‐life cardiovascular risk has been linked to a faster cognitive decline6 and a higher risk of dementia in later life.7 In addition, abdominal visceral fat has been associated with poor cognitive performance.8 Thus, the menopause transition may be a stage of vulnerability for subsequent cognitive impairment and dementia. Characterizing risk factors that deteriorate across the menopause transition may aid in early prevention of dementia, a disease with a natural history of pathological changes spanning decades starting in mid‐life.9Cardiovascular fat is a novel CVD risk factor10–15 that was found to be higher after than before menopause.16 Cardiovascular fat consists of epicardial adipose tissue (EAT; located within the pericardial sac), paracardial adipose tissue (PAT; outside the pericardial sac), and thoracic perivascular adipose tissue (PVAT; surrounding the descending thoracic aorta). Human EAT and PAT morphologically resemble white and beige

Journal

Alzheimer s & DementiaWiley

Published: Sep 1, 2023

Keywords: epicardial adipose tissue; episodic memory; mediastinal fat; menopause; paracardial adipose tissue; processing speed; thoracic perivascular adipose tissue; working memory

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