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Time for circadian medicine

Time for circadian medicine Circadian medicine developed from chronobiology, which deals with temporal processes in biological systems. Humans have an internal circadian clock that it is genetically determined, synchronized with the environment by light and food, and controls myriad time‐of‐day‐dependent physiological processes in each cell of our body.1,2 In 2017, Rosbash, Hall and Young received the Nobel Prize in Physiology or Medicine for elucidating the molecular mechanism of the circadian clock. In addition, the incidence and symptoms of many diseases vary with the time of day. Shift work and other environmental factors disrupting our clock are associated with common diseases. Vice versa, various maladies perturb physiological rhythms, such as the sleep–wake cycle. Chronobiology allows us to study such relationships mechanistically, for example by genetic models.The evidence is now overwhelming: An intact, well‐synchronized circadian clock is crucial for health. Modern environmental factors such as shift work, travel across time zones, irregular diet, light pollution or social jetlag are on the rise in our 24/7 society and increase the risk of disease by disrupting or misaligning the circadian clock. Moreover, in many pathologies, circadian rhythms are disturbed, thus a disrupted clock may also be a symptom of disease. Because of multiple feedbacks, circadian disruption and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Acta Physiologica Wiley

Time for circadian medicine

Acta Physiologica , Volume 238 (3) – Jul 1, 2023

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References (36)

Publisher
Wiley
Copyright
Copyright © 2023 Scandinavian Physiological Society
ISSN
1748-1708
eISSN
1748-1716
DOI
10.1111/apha.13984
Publisher site
See Article on Publisher Site

Abstract

Circadian medicine developed from chronobiology, which deals with temporal processes in biological systems. Humans have an internal circadian clock that it is genetically determined, synchronized with the environment by light and food, and controls myriad time‐of‐day‐dependent physiological processes in each cell of our body.1,2 In 2017, Rosbash, Hall and Young received the Nobel Prize in Physiology or Medicine for elucidating the molecular mechanism of the circadian clock. In addition, the incidence and symptoms of many diseases vary with the time of day. Shift work and other environmental factors disrupting our clock are associated with common diseases. Vice versa, various maladies perturb physiological rhythms, such as the sleep–wake cycle. Chronobiology allows us to study such relationships mechanistically, for example by genetic models.The evidence is now overwhelming: An intact, well‐synchronized circadian clock is crucial for health. Modern environmental factors such as shift work, travel across time zones, irregular diet, light pollution or social jetlag are on the rise in our 24/7 society and increase the risk of disease by disrupting or misaligning the circadian clock. Moreover, in many pathologies, circadian rhythms are disturbed, thus a disrupted clock may also be a symptom of disease. Because of multiple feedbacks, circadian disruption and

Journal

Acta PhysiologicaWiley

Published: Jul 1, 2023

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