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A. Luetz, Julius Grunow, R. Mörgeli, M. Rosenthal, S. Weber-Carstens, B. Weiss, C. Spies (2019)
Innovative ICU Solutions to Prevent and Reduce Delirium and Post–Intensive Care Unit SyndromeSeminars in Respiratory and Critical Care Medicine, 40
M. Amir, Sweena Chaudhari, Ran Wang, S. Campbell, S. Mosure, Laura Chopp, Q. Lu, J. Shang, Oliver Pelletier, Yuanjun He, Christelle Doebelin, M. Cameron, D. Kojetin, T. Kamenecka, L. Solt (2018)
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The circadian neurobiology of rewardActa Physiologica, 237
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Dysfunction of circadian and sleep rhythms in the early stages of Alzheimer's diseaseActa Physiologica, 238
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The role of the circadian clock in the development, progression, and treatment of non‐alcoholic fatty liver diseaseActa Physiologica, 237
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Mammalian circadian systems: Organization and modern life challengesActa Physiologica, 231
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Circadian and Sleep Dysfunctions in Neurodegenerative Disorders—An UpdateFrontiers in Neuroscience, 14
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Circadian rhythms in auditory hallucinations and psychosisActa Physiologica, 237
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Circadian medicine developed from chronobiology, which deals with temporal processes in biological systems. Humans have an internal circadian clock that it is genetically determined, synchronized with the environment by light and food, and controls myriad time‐of‐day‐dependent physiological processes in each cell of our body.1,2 In 2017, Rosbash, Hall and Young received the Nobel Prize in Physiology or Medicine for elucidating the molecular mechanism of the circadian clock. In addition, the incidence and symptoms of many diseases vary with the time of day. Shift work and other environmental factors disrupting our clock are associated with common diseases. Vice versa, various maladies perturb physiological rhythms, such as the sleep–wake cycle. Chronobiology allows us to study such relationships mechanistically, for example by genetic models.The evidence is now overwhelming: An intact, well‐synchronized circadian clock is crucial for health. Modern environmental factors such as shift work, travel across time zones, irregular diet, light pollution or social jetlag are on the rise in our 24/7 society and increase the risk of disease by disrupting or misaligning the circadian clock. Moreover, in many pathologies, circadian rhythms are disturbed, thus a disrupted clock may also be a symptom of disease. Because of multiple feedbacks, circadian disruption and
Acta Physiologica – Wiley
Published: Jul 1, 2023
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