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- Copyright
- Copyright © 2015 by the Southern Society for Clinical Investigation.
- ISSN
- 0002-9629
- eISSN
- 1538-2990
- DOI
- 10.1097/MAJ.0000000000000556
- pmid
- 26351776
- Publisher site
- See Article on Publisher Site
Abstract
CLINICAL INVESTIGATION A Pilot Randomized Controlled Trial of Vitamin D Repletion to Determine if Endothelial Function Improves in Patients With Systemic Lupus Erythematosus Diane L. Kamen, MD and Jim C. Oates, MD activity in the absence of infection or inflammatory stimuli. Abstract: Background: The endothelium is important not only in Nitric oxide (NO) produced by eNOS is a biosensor response regulating vascular tone but also in modulating inflammation. Patients that modifies locally expressed signaling proteins in response to with systemic lupus erythematosus (SLE) have deficits in these 6–9 signaling for changes in eNOS activity. Lack of functional endothelial functions. Vitamin D is a nuclear hormone that regulates eNOS in murine lupus leads to accelerated vascular plaque vascular endothelial nitric oxide synthase activity and expression. Many formation. Thus, strategies to improve eNOS function may SLE patients have insufficient levels of vitamin D. The effect of this reduce inflammation in SLE. hormone on vascular endothelial function in SLE patients is not known. Vitamin D deficiency is seen in patients with lupus, with This study was designed to determine the effect size of repleting vitamin season, glucocorticoid exposure, darker skin, renal disease and D levels on endothelial function in patients with SLE
Journal
American Journal of the Medical Sciences – Wolters Kluwer Health
Published: Sep 1, 2015