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A Possible Case of Opioid-Induced Hypoglycemia and the Potential Role of Naloxone

A Possible Case of Opioid-Induced Hypoglycemia and the Potential Role of Naloxone Literature has found that individuals with opioid use disorders have increased fasting insulin levels and that antagonism of the μ-receptor with naloxone blunted this hypoglycemic effect. We describe a 35-year-old woman with no history of diabetes who presented after being found unconscious where she was given naloxone and became awake and combative. Her blood glucose (BG) on presentation was 175 mg/dl, which declined to 40 mg/dl, and dextrose was administered. Subsequently, it declined to 42 mg/dl and was again given dextrose. Later her BG fell to 67 mg/dl and she was given dextrose and started on a dextrose infusion. She was then administered IV naloxone and 1 hr later the infusion was discontinued and she had no further hypoglycemic events. Clinicians should consider altering monitoring parameters in the setting of acute overdoses to include repeated glucose assessment to ensure early identification of hypoglycemia and the potential influence of naloxone. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Advanced Emergency Nursing Journal Wolters Kluwer Health

A Possible Case of Opioid-Induced Hypoglycemia and the Potential Role of Naloxone

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References (20)

Publisher
Wolters Kluwer Health
Copyright
© 2023 Wolters Kluwer Health, Inc. All rights reserved.
ISSN
1931-4485
eISSN
1931-4493
DOI
10.1097/tme.0000000000000460
Publisher site
See Article on Publisher Site

Abstract

Literature has found that individuals with opioid use disorders have increased fasting insulin levels and that antagonism of the μ-receptor with naloxone blunted this hypoglycemic effect. We describe a 35-year-old woman with no history of diabetes who presented after being found unconscious where she was given naloxone and became awake and combative. Her blood glucose (BG) on presentation was 175 mg/dl, which declined to 40 mg/dl, and dextrose was administered. Subsequently, it declined to 42 mg/dl and was again given dextrose. Later her BG fell to 67 mg/dl and she was given dextrose and started on a dextrose infusion. She was then administered IV naloxone and 1 hr later the infusion was discontinued and she had no further hypoglycemic events. Clinicians should consider altering monitoring parameters in the setting of acute overdoses to include repeated glucose assessment to ensure early identification of hypoglycemia and the potential influence of naloxone.

Journal

Advanced Emergency Nursing JournalWolters Kluwer Health

Published: Apr 1, 2023

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