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CLINICAL PATHOLOGIC CHALLENGE Vicente Sabater-Marco, MD,* Lara Navarro Cerveró, MD,* Violeta Zaragoza Ninet, MD,† and Núria Santonja López, MD* (Am J Dermatopathol 2023;45:e45–e47) negative for epithelial membrane antigen, HMB45, melan A, desmin, calponin, CD10, STAT6, and SOX10. CASE REPORT Fluorescence in situ hybridization analysis did not A 16-year-old adolescent consulted the dermatology detect the t(17;22), resulting in the collagen type-1 alpha 1, service for an 4 x 3-cm ulcerated vulvar mass causing platelet-derived growth factor ß fusion gene. thickening of the right labia majora (Fig. 1). A partial biopsy Next-generation sequencing analysis, using the Oncomine revealed a mesenchymal proliferation infiltrating the entire Precision-GX5-Solid tumor w2.6.0 Fusion Panel (Thermo dermis and subcutis (Fig. 2a). The neoplastic cells were Fisher Scientific), detected the NTRK1-TPM3 gene fusion. spindle-shaped; they were arranged in long fascicles The patient underwent a complete excision of the (Fig. 2b) and infiltrated the adipose tissue (Fig. 2c). The vulvar mass with free surgical margins. The tumor nodule spindle cells showed mild cytological atypia, elongated was solid, well-circumscribed, and yellowish (Fig. 4). After nuclei, and large cytoplasm (Fig. 2d). There were 6 mitotic 10 months of diagnosis, the patient is well without figures per 20 high-power fields and no
The American Journal of Dermatopathology – Wolters Kluwer Health
Published: Jun 1, 2023
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