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Antibiotic Dosing in Critically Ill Patients Undergoing Renal Replacement Therapy

Antibiotic Dosing in Critically Ill Patients Undergoing Renal Replacement Therapy AACN Advanced Critical Care Volume 26, Number 3, pp. 244-251 © 2015 AACN Antibiotic Dosing in Critically Ill Patients Undergoing Renal Replacement Therapy Gregory M. Susla, PharmD ABSTRACT Continuous renal replacement therapy is fre- Antibiotic dosing regimens must then be quently used to manage acute renal failure continuously monitored and adjusted in critically ill patients. Antibiotic drugs used according to modifications made to the renal to treat infections in critically ill patients replacement circuit and the patient's under- need to be dosed on the basis of the method lying condition. of renal replacement therapy to be used, Keywords: acute renal failure, antibiotics, degree of residual renal function, and the continuous renal replacement therapy, dialy- sensitivity of the organism to be treated. sis, drug dosing nfections are a common occurrence in criti- balance and aid in the removal of metabolic Ically ill patients, with the most common breakdown products from the body. Unfortu- infections being respiratory, abdominal, uri- nately, medications are also removed during 1,2 nary tract, and blood stream. These infec- RRT, and dosing regimens may need to be tions are often due to multidrug-resistant adjusted to account for this removal. bacteria such as Acinetobacter species, Pseu- domonas aeruginosa, http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png AACN Advanced Critical Care Wolters Kluwer Health

Antibiotic Dosing in Critically Ill Patients Undergoing Renal Replacement Therapy

Susla, Gregory M.
AACN Advanced Critical Care , Volume 26 (3) – Jul 1, 2015
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Copyright
© 2015 American Association of Critical-Care Nurses
ISSN
1559-7768
eISSN
1559-7776
DOI
10.1097/NCI.0000000000000098
pmid
26200733
Publisher site
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Abstract

AACN Advanced Critical Care Volume 26, Number 3, pp. 244-251 © 2015 AACN Antibiotic Dosing in Critically Ill Patients Undergoing Renal Replacement Therapy Gregory M. Susla, PharmD ABSTRACT Continuous renal replacement therapy is fre- Antibiotic dosing regimens must then be quently used to manage acute renal failure continuously monitored and adjusted in critically ill patients. Antibiotic drugs used according to modifications made to the renal to treat infections in critically ill patients replacement circuit and the patient's under- need to be dosed on the basis of the method lying condition. of renal replacement therapy to be used, Keywords: acute renal failure, antibiotics, degree of residual renal function, and the continuous renal replacement therapy, dialy- sensitivity of the organism to be treated. sis, drug dosing nfections are a common occurrence in criti- balance and aid in the removal of metabolic Ically ill patients, with the most common breakdown products from the body. Unfortu- infections being respiratory, abdominal, uri- nately, medications are also removed during 1,2 nary tract, and blood stream. These infec- RRT, and dosing regimens may need to be tions are often due to multidrug-resistant adjusted to account for this removal. bacteria such as Acinetobacter species, Pseu- domonas aeruginosa,

Journal

AACN Advanced Critical Care – Wolters Kluwer Health

Published: Jul 1, 2015

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