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CASE-LETTER which was confirmed by an outside reference laboratory Cryptococcus uniguttulatus Meningitis (Quest Diagnostics, Madison, MJ). Magnetic resonance imag- ing of the brain showed no evidence of parenchymal disease or hydrocephalus. The patient received 4 days of intravenous liposomal amphotericin B (5 mg/kg daily) with rapid improvement in on–neoformans cryptococci are generally regarded as her headache and nausea. Oral fluconazole 400 mg twice N saprophytes and are rarely reported as human patho- daily was given at discharge and changed to voriconazole gens. Cryptococcus uniguttulatus is encountered less fre- after susceptibility test results were received (Table 1). After quently in humans than are C laurentii and C albidus.The 2 weeks of voriconazole treatment, repeat CSF fungal cul- latter species are rare causes of fungemia, pneumonia, cen- ture was negative and the pleocytosis had resolved. The tral nervous system (CNS) infections and of skin and lung patient completed 4 months of voriconazole therapy and abscesses. Cryptococci are found in the environment, has had no evidence of recurrence of cryptococcal infection mainly in soil and vegetation and also bird droppings. after 1 year. Human colonization with C uniguttulatus has been C uniguttulatus was first characterized in 1934 by Wol- reported. Immunosuppression plays
American Journal of the Medical Sciences – Wolters Kluwer Health
Published: Sep 1, 2015
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