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Zhong-li Wang, Kexuan Zhu, Lin Chen, L. Yang, Yu-fang Huang, Yunan Zhao (2015)
Preventive effects of ginsenoside Rg1 on post-traumatic stress disorder (PTSD)-like behavior in male C57/B6 miceNeuroscience Letters, 605
N. Abolhasanpour, A. Eidi, S. Hajebrahimi, S. Reyhani-Rad, H. Hashim (2019)
Effect of cerebrolysin on bladder function after spinal cord injury in female Wistar ratsInternational Journal of Urology, 26
Meenu Verma, Anjana Bali, Nirmal Singh, A. Jaggi (2016)
Investigating the role of nisoldipine in foot‐shock‐induced post‐traumatic stress disorder in miceFundamental & Clinical Pharmacology, 30
B. Xiao, F. Han, Yuxiu Shi (2019)
Administration of moclobemide facilitates fear extinction and attenuates anxiety‐like behaviors by regulating synaptic‐associated proteins in a rat model of post‐traumatic stress disorderSynapse, 74
A. Bahi (2017)
Environmental enrichment reduces chronic psychosocial stress-induced anxiety and ethanol-related behaviors in miceProgress in Neuro-Psychopharmacology and Biological Psychiatry, 77
Ryan Wright, C. Conrad (2008)
Enriched environment prevents chronic stress-induced spatial learning and memory deficitsBehavioural Brain Research, 187
Junxia Luo, Lin Zhang, N. Ning, Hong Jiang, S. Yu (2013)
Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in ratBehavioural Brain Research, 253
S. Vatandoust, G. Meftahi (2022)
The Effect of Sericin on the Cognitive Impairment, Depression, and Anxiety Caused by Learned Helplessness in Male MiceJournal of Molecular Neuroscience, 72
S. Sadigh-Eteghad, M. Geranmayeh, A. Majdi, Farzad Salehpour, J. Mahmoudi, M. Farhoudi (2018)
Intranasal cerebrolysin improves cognitive function and structural synaptic plasticity in photothrombotic mouse model of medial prefrontal cortex ischemiaNeuropeptides, 71
K. Alzoubi, O. Khabour, Mohammed Ahmed (2018)
Pentoxifylline prevents post-traumatic stress disorder induced memory impairmentBrain Research Bulletin, 139
J. Veena, B. Srikumar, K. Mahati, V. Bhagya, T. Raju, B. Rao (2009)
Enriched environment restores hippocampal cell proliferation and ameliorates cognitive deficits in chronically stressed ratsJournal of Neuroscience Research, 87
M. Kumar, Nirmal Singh, A. Jaggi (2020)
Exploring the anti-stress effects of imatinib and tetrabenazine in cold-water immersion-induced acute stress in miceNaunyn-Schmiedeberg's Archives of Pharmacology, 393
Jin-Hee Seo, Hye-Sang Park, Sang-Seo Park, Chang-Ju Kim, Dong-Hyun Kim, Tae-Woon Kim (2019)
Physical exercise ameliorates psychiatric disorders and cognitive dysfunctions by hippocampal mitochondrial function and neuroplasticity in post-traumatic stress disorderExperimental Neurology, 322
A. Würz, M. Sungur (2009)
Combining cognitive behavioural therapy and pharmacotherapy in the treatment of anxiety disorders: True gains or false hopes?Klinik Psikofarmakoloji Bulteni-bulletin of Clinical Psychopharmacology, 19
H. Kaur, Ravjot Kaur, A. Jaggi, Anjana Bali (2020)
Beneficial role of central anticholinergic agent in preventing the development of symptoms in mouse model of post-traumatic stress disorderJournal of Basic and Clinical Physiology and Pharmacology, 31
Mira Jakovcevski, Melitta Schachner, Melitta Schachner, F. Morellini (2008)
Individual variability in the stress response of C57BL/6J male mice correlates with trait anxietyGenes, 7
L. Novaes, N. Santos, Juliano Perfetto, K. Goosens, C. Munhoz (2018)
Environmental enrichment prevents acute restraint stress-induced anxiety-related behavior but not changes in basolateral amygdala spine densityPsychoneuroendocrinology, 98
Koroush Gharagozli, A. Harandi, S. Houshmand, N. Akbari, D. Muresanu, J. Vester, S. Winter, Herbert Moessler (2017)
Efficacy and safety of Cerebrolysin treatment in early recovery after acute ischemic stroke: a randomized, placebo-controlled, double-blinded, multicenter clinical trialJournal of Medicine and Life, 10
M. Uddin, L. Sipahi, Jia Li, K. Koenen (2013)
SEX DIFFERENCES IN DNA METHYLATION MAY CONTRIBUTE TO RISK OF PTSD AND DEPRESSION: A REVIEW OF EXISTING EVIDENCEDepression and Anxiety, 30
Würz (2009)
436Bull Clin Psychopharmacol, 19
I. Zovkic, Jarrod Meadows, Garrett Kaas, J. Sweatt, T. Roth (2013)
Interindividual Variability in Stress Susceptibility: A Role for Epigenetic Mechanisms in PTSDFrontiers in Psychiatry, 4
V. Bhagya, B. Srikumar, J. Veena, B. Rao (2017)
Short‐term exposure to enriched environment rescues chronic stress‐induced impaired hippocampal synaptic plasticity, anxiety, and memory deficitsJournal of Neuroscience Research, 95
Chia‐Chi Hung, Chun-Hua Lin, H. Chang, Chen-Yu Wang, Shang Lin, Pei‐Chien Hsu, Yu-Yo Sun, Teng-Nan Lin, F. Shie, L. Kao, C. Chou, Yi-Hsuan Lee (2016)
Astrocytic GAP43 Induced by the TLR4/NF-κB/STAT3 Axis Attenuates Astrogliosis-Mediated Microglial Activation and NeurotoxicityThe Journal of Neuroscience, 36
Chao‐Yueh Su, Kuan-Yi Tsai, F. Chou, Wen-Wei Ho, Renyi Liu, W. Lin (2010)
A three‐year follow‐up study of the psychosocial predictors of delayed and unresolved post‐traumatic stress disorder in Taiwan Chi‐Chi earthquake survivorsPsychiatry and Clinical Neurosciences, 64
K. Alzoubi, Z. Subeh, O. Khabour (2017)
Evaluating the protective effect of etazolate on memory impairment, anxiety- and depression-like behaviors induced by post traumatic stress disorderBrain Research Bulletin, 135
Ravjot Kaur, A. Jaggi, Anjana Bali (2019)
To investigate the role of Withania somnifera in a mouse model of posttraumatic stress disorderHeart and Mind, 3
Narmin Farazi, J. Mahmoudi, S. Sadigh-Eteghad, F. Farajdokht, S. Rasta (2021)
Synergistic effects of combined therapy with transcranial photobiomodulation and enriched environment on depressive- and anxiety-like behaviors in a mice model of noise stressLasers in Medical Science, 37
L. Hosseini, Narmin Farazi, Marjan Erfani, J. Mahmoudi, M. Akbari, S. Hosseini, S. Sadigh-Eteghad (2021)
Effect of transcranial near-infrared photobiomodulation on cognitive outcomes in D-galactose/AlCl3 induced brain aging in BALB/c miceLasers in Medical Science, 37
J. Mahmoudi, L. Hosseini, S. Sadigh-Eteghad, F. Farajdokht, S. Vatandoust, Mojtaba Zn785iaee (2021)
Sericin Alleviates Thermal Stress Induced Anxiety-Like Behavior and Cognitive Impairment Through Regulation of Oxidative Stress, Apoptosis, and Heat-Shock Protein-70 in the HippocampusNeurochemical Research, 46
K. Nichol, Sean Deeny, Joseph Seif, Kevin Camaclang, C. Cotman (2009)
Exercise improves cognition and hippocampal plasticity in APOE ε4 miceAlzheimer's & Dementia, 5
Rajneet Manchanda, A. Jaggi, Nirmal Singh (2011)
Ameliorative potential of sodium cromoglycate and diethyldithiocarbamic acid in restraint stress-induced behavioral alterations in rats.Pharmacological reports : PR, 63 1
A. Agrawal, A. Jaggi, Nirmal Singh (2011)
Pharmacological investigations on adaptation in rats subjected to cold water immersion stressPhysiology & Behavior, 103
D. Stairs, Nicole Chacho, Connor Wunsch, Lauren Pipitone, S. Dravid (2020)
Environmental enrichment increases cue-dependent freezing and behavioral despair but decreases anxiety-like behavior in ratsPharmacology Biochemistry and Behavior, 196
T. Koyuncuoğlu, H. Sevim, N. Çetrez, Z. Meral, Berfin Gönenç, E. Dertsiz, D. Akakın, M. Yüksel, Ö. Çakır (2020)
High intensity interval training protects from Post Traumatic Stress Disorder induced cognitive impairmentBehavioural Brain Research, 397
Gharagozli (2017)
153J Med Life, 10
K. Alzoubi, Alaa Al-ibbini, K. Nuseir (2018)
Prevention of memory impairment induced by post-traumatic stress disorder by cerebrolysinPsychiatry Research, 270
Zhijuan Liu, Ming Hu, Peiyuan Lu, Hebo Wang, Qianqian Qi, Jing Xu, Yining Xiao, M. Fan, Yanqiu Jia, Dandan Zhang (2017)
Cerebrolysin alleviates cognitive deficits induced by chronic cerebral hypoperfusion by increasing the levels of plasticity-related proteins and decreasing the levels of apoptosis-related proteins in the rat hippocampusNeuroscience Letters, 651
Asmae Lguensat, Zineb Boudjafad, E. Giorla, M. Bennis, C. Baunez, R. Garcia, S. Ba-M'hamed (2021)
Repeated ethanol exposure following avoidance conditioning impairs avoidance extinction and modifies conditioning‐associated prefrontal dendritic changes in a mouse model of post‐traumatic stress disorderEuropean Journal of Neuroscience, 54
L. Vaghef, F. Farajdokht, Marjan Erfani, A. Majdi, S. Sadigh-Eteghad, Pouran Karimi, Siamak Shotorbani, Manouchehr Vafaee, J. Mahmoudi (2019)
Cerebrolysin attenuates ethanol-induced spatial memory impairments through inhibition of hippocampal oxidative stress and apoptotic cell death in rats.Alcohol, 79
D. Bangasser, T. Shors (2007)
The hippocampus is necessary for enhancements and impairments of learning following stressNature Neuroscience, 10
D. Bastien (2010)
Pharmacological treatment of combat-induced PTSD: a literature review.British journal of nursing, 19 5
J. Nithianantharajah, A. Hannan (2006)
Enriched environments, experience-dependent plasticity and disorders of the nervous systemNature Reviews Neuroscience, 7
Ehsan Pourmemar, A. Majdi, Morteza Haramshahi, M. Talebi, Pouran Karimi, S. Sadigh-Eteghad (2017)
Intranasal Cerebrolysin Attenuates Learning and Memory Impairments in D-galactose-Induced Senescence in MiceExperimental Gerontology, 87
Katharina Gapp, J. Bohacek, J. Grossmann, A. Brunner, Francesca Manuella, P. Nanni, I. Mansuy (2016)
Potential of Environmental Enrichment to Prevent Transgenerational Effects of Paternal TraumaNeuropsychopharmacology, 41
P. Marianno, K. Abrahao, R. Camarini (2017)
Environmental Enrichment Blunts Ethanol Consumption after Restraint Stress in C57BL/6 MicePLoS ONE, 12
Ling Chen, Kaiping Liu, Yulu Wang, Na Liu, Minjie Yao, Jinghan Hu, Gang Wang, Yindi Sun, Jianchun Pan (2020)
Phosphodiesterase-2 inhibitor reverses post-traumatic stress induced fear memory deficits and behavioral changes via cAMP/cGMP pathway.European journal of pharmacology
Zeguo Zhang, Zhi-kun Qiu, Jia-Li He, Xu Liu, Ji-sheng Chen, Yulu Wang (2017)
Resveratrol ameliorated the behavioral deficits in a mouse model of post-traumatic stress disorderPharmacology Biochemistry and Behavior, 161
F. Farajdokht, Farnaz Oghbaei, S. Sadigh-Eteghad, A. Majdi, Sepideh Aghsan, M. Farhoudi, Nazila Vahidi-eyrisofla, J. Mahmoudi (2022)
Cerebrolysin® and environmental enrichment, alone or in combination, ameliorate anxiety- and depressive-like behaviors in a post-ischemic depression model in mice.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 31 7
Carlos Solis-Gaspar, R. Vázquez-Roque, Ma Gomez-Villalobos, G. Flores (2016)
Cerebrolysin improves memory and ameliorates neuronal atrophy in spontaneously hypertensive, aged ratsSynapse, 70
M. Mallory, W. Honer, L. Hsu, Robert Johnson, E. Rockenstein, E. Masliah (1999)
In vitro synaptotrophic effects of Cerebrolysin in NT2N cellsActa Neuropathologica, 97
Edda Windholz, A. Gschanes, M. Windisch, Günter Fachbach (1999)
Two Peptidergic Drugs Increase the Synaptophysin Immunoreactivity in Brains of 6-week-old RatsThe Histochemical Journal, 32
I. Reinprecht, A. Gschanes, M. Windisch, Günter Fachbach (2004)
Two Peptidergic Drugs Increase the Synaptophysin Immunoreactivity in Brains of 24-month-old RatsThe Histochemical Journal, 31
S. Garfinkel, J. Abelson, A. King, Rebecca Sripada, Xin Wang, LauraM Gaines, I. Liberzon (2014)
Impaired Contextual Modulation of Memories in PTSD: An fMRI and Psychophysiological Study of Extinction Retention and Fear RenewalThe Journal of Neuroscience, 34
Zeng Jin, Jin-Xu Liu, Xu Liu, Li-ming Zhang, Yu-hua Ran, Yuan-yuan Zheng, Yu Tang, Yun‐feng Li, J. Xiong (2016)
Anxiolytic effects of GLYX-13 in animal models of posttraumatic stress disorder-like behaviorJournal of Psychopharmacology, 30
Aalamjeet Kaur, Anjana Bali, Nirmal Singh, A. Jaggi (2015)
Investigating the stress attenuating potential of furosemide in immobilization and electric foot-shock stress models in miceNaunyn-Schmiedeberg's Archives of Pharmacology, 388
Chuguang Wei, Jin Han, Yuqing Zhang, Walter Hannak, Zhengkui Liu (2017)
The Characteristics of Emotional Response of Post-traumatic Stress Disorder and Post-traumatic Growth among Chinese Adults Exposed to an Explosion IncidentFrontiers in Public Health, 5
F. Farajdokht, Seyed Vatandoust, L. Hosseini, K. Fekri, Sepideh Aghsan, A. Majdi, S. Sadigh-Eteghad, J. Mahmoudi (2021)
Sericin protects against acute sleep deprivation-induced memory impairment via enhancement of hippocampal synaptic protein levels and inhibition of oxidative stress and neuroinflammation in miceBrain Research Bulletin, 174
S. Morita, S. Miyata (2013)
Synaptic localization of growth‐associated protein 43 in cultured hippocampal neurons during synaptogenesisCell Biochemistry and Function, 31
X. Alvarez, R. Cacabelos, M. Laredo, V. Couceiro, C. Sampedro, M. Varela, L. Corzo, L. Fernández-Novoa, M. Vargas, M. Aleixandre, C. Linares, E. Granizo, D. Muresanu, H. Moessler (2006)
A 24‐week, double‐blind, placebo‐controlled study of three dosages of Cerebrolysin in patients with mild to moderate Alzheimer's diseaseEuropean Journal of Neurology, 13
Eva-Gunnel Ducourneau, C. Guette, Damien Perrot, Miguel Mondésir, C. Mombereau, J. Arnt, A. Desmedt, P. Piazza (2020)
Brexpiprazole blocks post-traumatic stress disorder-like memory while promoting normal fear memoryMolecular Psychiatry, 26
Posttraumatic stress disorder (PTSD) is a serious neuropsychiatric disorder that occurs after exposure to stressful, fearful, or troubling events. Cerebrolysin (CBL), consists of low molecular weights neurotrophic factors and amino acids obtained from purified porcine brain proteins. This study aimed to evaluate the possible therapeutic effects of enriched environment (EE) and CBL alone or combined for reducing anxiety and cognitive deficits in PTSD-like mouse models. For this purpose, inescapable electric foot shocks were delivered to Balb/c mice for two consecutive days. Then mice were treated with CBL (2.5 mL/kg) and/or were kept in EE (2 h per day) or received their combination for 14 consecutive days. The hole-board test and Lashley III paradigm were used to assess anxiety and spatial learning and memory, respectively. Changes in the serum corticosterone level and expression of synaptic elements, including; growth-associated protein 43, post-synaptic density 95, and synaptophysin were assessed in the hippocampus. This model caused anxiety and spatial memory impairment associated with increased serum corticosterone levels and decreased synaptic elements. Nevertheless, CBL and/or combination treatment could reverse behavioral and molecular alterations. Our findings indicated that CBL, separately or in combination with EE, is effective in reducing anxiety and spatial memory impairment in PTSD-like mice.
Behavioural Pharmacology – Wolters Kluwer Health
Published: Jun 10, 2023
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